Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes
Background: Achilles tendon ruptures (ATRs) often occur in competitive athletes. Various studies have been conducted to improve the treatment outcomes for ATRs, but the results remain unsatisfactory for athletes. Purpose: To review our experiences of adding injections of freeze-dried platelet-derive...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-12-01
|
| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425001233 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850184252845457408 |
|---|---|
| author | Shota Morimoto Futoshi Morio Yuta Matsumae Masashi Nakamura Yoshitaka Nakao Toshiya Tachibana Tomoya Iseki |
| author_facet | Shota Morimoto Futoshi Morio Yuta Matsumae Masashi Nakamura Yoshitaka Nakao Toshiya Tachibana Tomoya Iseki |
| author_sort | Shota Morimoto |
| collection | DOAJ |
| description | Background: Achilles tendon ruptures (ATRs) often occur in competitive athletes. Various studies have been conducted to improve the treatment outcomes for ATRs, but the results remain unsatisfactory for athletes. Purpose: To review our experiences of adding injections of freeze-dried platelet-derived factor concentrate (FD-PFC) to surgical treatment with an early rehabilitation for ATRs in high-level athletes. Methods: We retrospectively analyzed 8 high-level athletes (Tegner activity score ≥8) with ATR, who received postoperative injection of FD-PFC in addition to surgical treatment with an early rehabilitation protocol between May 2019 and November 2021. In all patients, surgery was performed using the modified side-locking loop suture technique, and an early rehabilitation protocol was implemented postoperatively. The prepared FD-PFC was injected into the Achilles tendon suture site under ultrasound guidance at 4 weeks postoperatively. Evaluation of the clinical outcomes included the following factor: the American Orthopedic Foot and Ankle Society ankle-hindfoot scale (AOFAS) score measured preoperatively and at one year postoperatively, time to ability to perform 20 continuous double- and single-leg heel raises (DHR/SHR), time to return to the original sport, and complications related to surgery or FD-PFC injection. In addition, magnetic resonance imaging (MRI) was performed for all patients at 12 and 24 weeks postoperatively to evaluate Achilles tendon maturation. Results: The 8 patients consisted of 7 males and one female athletes with a mean age of 28.5 ± 5.2 years (range, 23–39 years) at the time of surgery. All patients were high-level athletes with a mean Tegner activity score of 9.0 ± 0.5 (range, 8–10). The mean AOFAS score improved significantly from 36.0 ± 9.4 preoperatively to 96.8 ± 3.6 at one year postoperatively (p < 0.001). The mean time to be able to perform 20 continuous DHR and 20 continuous SHR was 6.8 ± 0.8 weeks and 10.1 ± 1.6 weeks, respectively. All patients could return to their original sport at pre-injury levels with the mean time of 18.3 ± 2.7 weeks. Also, there were no complications related to surgery or injection. Furthermore, T2-weighted MRI showed the high signal intensity of the sutured tendon in 25 % (2 of 8 patients) at 12 weeks and 0 % (0 of 8 patients) at 24 weeks postoperatively. Conclusions: The addition of FD-PFC injections to surgical treatment with an early rehabilitation protocol could provide satisfactory results for high-level athletes with ATRs, enabling them early return to their original sports at pre-injury level. This treatment option may be useful for athletes with ATRs. |
| format | Article |
| id | doaj-art-d24eeb51af214d4bba70fab25e093b6c |
| institution | OA Journals |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-d24eeb51af214d4bba70fab25e093b6c2025-08-20T02:17:05ZengElsevierRegenerative Therapy2352-32042025-12-013010711110.1016/j.reth.2025.05.007Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletesShota Morimoto0Futoshi Morio1Yuta Matsumae2Masashi Nakamura3Yoshitaka Nakao4Toshiya Tachibana5Tomoya Iseki6Corresponding author.; Department of Orthopaedic Surgery, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, JapanDepartment of Orthopaedic Surgery, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, JapanDepartment of Orthopaedic Surgery, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, JapanDepartment of Orthopaedic Surgery, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, JapanDepartment of Orthopaedic Surgery, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, JapanDepartment of Orthopaedic Surgery, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, JapanDepartment of Orthopaedic Surgery, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, JapanBackground: Achilles tendon ruptures (ATRs) often occur in competitive athletes. Various studies have been conducted to improve the treatment outcomes for ATRs, but the results remain unsatisfactory for athletes. Purpose: To review our experiences of adding injections of freeze-dried platelet-derived factor concentrate (FD-PFC) to surgical treatment with an early rehabilitation for ATRs in high-level athletes. Methods: We retrospectively analyzed 8 high-level athletes (Tegner activity score ≥8) with ATR, who received postoperative injection of FD-PFC in addition to surgical treatment with an early rehabilitation protocol between May 2019 and November 2021. In all patients, surgery was performed using the modified side-locking loop suture technique, and an early rehabilitation protocol was implemented postoperatively. The prepared FD-PFC was injected into the Achilles tendon suture site under ultrasound guidance at 4 weeks postoperatively. Evaluation of the clinical outcomes included the following factor: the American Orthopedic Foot and Ankle Society ankle-hindfoot scale (AOFAS) score measured preoperatively and at one year postoperatively, time to ability to perform 20 continuous double- and single-leg heel raises (DHR/SHR), time to return to the original sport, and complications related to surgery or FD-PFC injection. In addition, magnetic resonance imaging (MRI) was performed for all patients at 12 and 24 weeks postoperatively to evaluate Achilles tendon maturation. Results: The 8 patients consisted of 7 males and one female athletes with a mean age of 28.5 ± 5.2 years (range, 23–39 years) at the time of surgery. All patients were high-level athletes with a mean Tegner activity score of 9.0 ± 0.5 (range, 8–10). The mean AOFAS score improved significantly from 36.0 ± 9.4 preoperatively to 96.8 ± 3.6 at one year postoperatively (p < 0.001). The mean time to be able to perform 20 continuous DHR and 20 continuous SHR was 6.8 ± 0.8 weeks and 10.1 ± 1.6 weeks, respectively. All patients could return to their original sport at pre-injury levels with the mean time of 18.3 ± 2.7 weeks. Also, there were no complications related to surgery or injection. Furthermore, T2-weighted MRI showed the high signal intensity of the sutured tendon in 25 % (2 of 8 patients) at 12 weeks and 0 % (0 of 8 patients) at 24 weeks postoperatively. Conclusions: The addition of FD-PFC injections to surgical treatment with an early rehabilitation protocol could provide satisfactory results for high-level athletes with ATRs, enabling them early return to their original sports at pre-injury level. This treatment option may be useful for athletes with ATRs.http://www.sciencedirect.com/science/article/pii/S2352320425001233Achilles tendon ruptureOperative treatmentEarly rehabilitationPlatelet-rich plasmaFreeze-dried platelet-derived factor concentrateAthlete |
| spellingShingle | Shota Morimoto Futoshi Morio Yuta Matsumae Masashi Nakamura Yoshitaka Nakao Toshiya Tachibana Tomoya Iseki Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes Regenerative Therapy Achilles tendon rupture Operative treatment Early rehabilitation Platelet-rich plasma Freeze-dried platelet-derived factor concentrate Athlete |
| title | Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes |
| title_full | Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes |
| title_fullStr | Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes |
| title_full_unstemmed | Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes |
| title_short | Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes |
| title_sort | clinical outcome of adding injection of freeze dried platelet derived factor concentrate to operative treatment accompanied by an early rehabilitation for achilles tendon rupture in high level athletes |
| topic | Achilles tendon rupture Operative treatment Early rehabilitation Platelet-rich plasma Freeze-dried platelet-derived factor concentrate Athlete |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425001233 |
| work_keys_str_mv | AT shotamorimoto clinicaloutcomeofaddinginjectionoffreezedriedplateletderivedfactorconcentratetooperativetreatmentaccompaniedbyanearlyrehabilitationforachillestendonruptureinhighlevelathletes AT futoshimorio clinicaloutcomeofaddinginjectionoffreezedriedplateletderivedfactorconcentratetooperativetreatmentaccompaniedbyanearlyrehabilitationforachillestendonruptureinhighlevelathletes AT yutamatsumae clinicaloutcomeofaddinginjectionoffreezedriedplateletderivedfactorconcentratetooperativetreatmentaccompaniedbyanearlyrehabilitationforachillestendonruptureinhighlevelathletes AT masashinakamura clinicaloutcomeofaddinginjectionoffreezedriedplateletderivedfactorconcentratetooperativetreatmentaccompaniedbyanearlyrehabilitationforachillestendonruptureinhighlevelathletes AT yoshitakanakao clinicaloutcomeofaddinginjectionoffreezedriedplateletderivedfactorconcentratetooperativetreatmentaccompaniedbyanearlyrehabilitationforachillestendonruptureinhighlevelathletes AT toshiyatachibana clinicaloutcomeofaddinginjectionoffreezedriedplateletderivedfactorconcentratetooperativetreatmentaccompaniedbyanearlyrehabilitationforachillestendonruptureinhighlevelathletes AT tomoyaiseki clinicaloutcomeofaddinginjectionoffreezedriedplateletderivedfactorconcentratetooperativetreatmentaccompaniedbyanearlyrehabilitationforachillestendonruptureinhighlevelathletes |