Caffeine's Vascular Mechanisms of Action
Caffeine is the most widely consumed stimulating substance in the world. It is found in coffee, tea, soft drinks, chocolate, and many medications. Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimula...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/834060 |
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| _version_ | 1832551907604824064 |
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| author | Darío Echeverri Félix R. Montes Mariana Cabrera Angélica Galán Angélica Prieto |
| author_facet | Darío Echeverri Félix R. Montes Mariana Cabrera Angélica Galán Angélica Prieto |
| author_sort | Darío Echeverri |
| collection | DOAJ |
| description | Caffeine is the most widely consumed stimulating substance in the world. It is found in coffee, tea, soft drinks, chocolate, and many medications. Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. In vascular smooth muscle cells its effect is predominantly a competitive inhibition of phosphodiesterase, producing an accumulation of cAMP and vasodilation. In addition, it blocks the adenosine receptors present in the vascular tissue to produce vasoconstriction. In this paper the main mechanisms of action of caffeine on the vascular tissue are described, in which it is shown that caffeine has some cardiovascular properties and effects which could be considered beneficial. |
| format | Article |
| id | doaj-art-d242bf6ebb394f3388f2832b32de8ab0 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-d242bf6ebb394f3388f2832b32de8ab02025-02-03T06:00:14ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322010-01-01201010.1155/2010/834060834060Caffeine's Vascular Mechanisms of ActionDarío Echeverri0Félix R. Montes1Mariana Cabrera2Angélica Galán3Angélica Prieto4Laboratorio de Investigación en Función Vascular, Departamento de Investigaciones, Fundación CardioInfantil—Instituto de Cardiología, Carrera 13b no. 163-85, Torre A, Piso 3., Bogotá, ColombiaLaboratorio de Investigación en Función Vascular, Departamento de Investigaciones, Fundación CardioInfantil—Instituto de Cardiología, Carrera 13b no. 163-85, Torre A, Piso 3., Bogotá, ColombiaLaboratorio de Investigación en Función Vascular, Departamento de Investigaciones, Fundación CardioInfantil—Instituto de Cardiología, Carrera 13b no. 163-85, Torre A, Piso 3., Bogotá, ColombiaLaboratorio de Investigación en Función Vascular, Departamento de Investigaciones, Fundación CardioInfantil—Instituto de Cardiología, Carrera 13b no. 163-85, Torre A, Piso 3., Bogotá, ColombiaLaboratorio de Investigación en Función Vascular, Departamento de Investigaciones, Fundación CardioInfantil—Instituto de Cardiología, Carrera 13b no. 163-85, Torre A, Piso 3., Bogotá, ColombiaCaffeine is the most widely consumed stimulating substance in the world. It is found in coffee, tea, soft drinks, chocolate, and many medications. Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. In vascular smooth muscle cells its effect is predominantly a competitive inhibition of phosphodiesterase, producing an accumulation of cAMP and vasodilation. In addition, it blocks the adenosine receptors present in the vascular tissue to produce vasoconstriction. In this paper the main mechanisms of action of caffeine on the vascular tissue are described, in which it is shown that caffeine has some cardiovascular properties and effects which could be considered beneficial.http://dx.doi.org/10.1155/2010/834060 |
| spellingShingle | Darío Echeverri Félix R. Montes Mariana Cabrera Angélica Galán Angélica Prieto Caffeine's Vascular Mechanisms of Action International Journal of Vascular Medicine |
| title | Caffeine's Vascular Mechanisms of Action |
| title_full | Caffeine's Vascular Mechanisms of Action |
| title_fullStr | Caffeine's Vascular Mechanisms of Action |
| title_full_unstemmed | Caffeine's Vascular Mechanisms of Action |
| title_short | Caffeine's Vascular Mechanisms of Action |
| title_sort | caffeine s vascular mechanisms of action |
| url | http://dx.doi.org/10.1155/2010/834060 |
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