Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Introduction. Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated w...
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/4164130 |
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| author | A. Rebonato L. Graziosi D. Maiettini E. Marino V. De Angelis L. Brunese S. Mosca G. Metro M. Rossi G. Orgera M. Scialpi A. Donini |
| author_facet | A. Rebonato L. Graziosi D. Maiettini E. Marino V. De Angelis L. Brunese S. Mosca G. Metro M. Rossi G. Orgera M. Scialpi A. Donini |
| author_sort | A. Rebonato |
| collection | DOAJ |
| description | Introduction. Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma. Methods. We retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE. We enrolled patients with different etiopathogeneses of hepatitis and histologically proven HCC not suitable for surgery. The overall study population was dichotomized in two groups according to the median NLR value and was analyzed also according to other prognostic factors. Results. The global median overall survival (OS) was 28 months. The OS in patients with high NLR was statistically significantly shorter than that in patients with low NLR. The following pretreatment variables were significantly associated with the OS in univariate analyses: age, Child-Pugh score, BCLC stage, INR, and NLR. Pretreated high NLR was an independently unfavorable factor for OS. Conclusion. NLR could be considered a good prognostic factor of survival useful to stratify patients that could benefit from TACE treatment. |
| format | Article |
| id | doaj-art-d23f5edbcf8d4e01a237ba78aa887dfc |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d23f5edbcf8d4e01a237ba78aa887dfc2025-02-03T06:06:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/41641304164130Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial ChemoembolizationA. Rebonato0L. Graziosi1D. Maiettini2E. Marino3V. De Angelis4L. Brunese5S. Mosca6G. Metro7M. Rossi8G. Orgera9M. Scialpi10A. Donini11Department of Radiology, University of Perugia, Perugia, ItalyDepartment of General and Emergency Surgery, University of Perugia, Perugia, ItalyDepartment of Radiology, University of Perugia, Perugia, ItalyDepartment of General and Emergency Surgery, University of Perugia, Perugia, ItalyDepartment of Medical Oncology, University of Perugia, Perugia, ItalyDepartment of Medicine and Health Sciences, University of Molise, Campobasso, ItalyDepartment of Radiology, University of Perugia, Perugia, ItalyDepartment of Medical Oncology, University of Perugia, Perugia, ItalyDepartment of Interventional Radiology, University La Sapienza, Rome, ItalyDepartment of Interventional Radiology, University La Sapienza, Rome, ItalyDepartment of Radiology, University of Perugia, Perugia, ItalyDepartment of General and Emergency Surgery, University of Perugia, Perugia, ItalyIntroduction. Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma. Methods. We retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE. We enrolled patients with different etiopathogeneses of hepatitis and histologically proven HCC not suitable for surgery. The overall study population was dichotomized in two groups according to the median NLR value and was analyzed also according to other prognostic factors. Results. The global median overall survival (OS) was 28 months. The OS in patients with high NLR was statistically significantly shorter than that in patients with low NLR. The following pretreatment variables were significantly associated with the OS in univariate analyses: age, Child-Pugh score, BCLC stage, INR, and NLR. Pretreated high NLR was an independently unfavorable factor for OS. Conclusion. NLR could be considered a good prognostic factor of survival useful to stratify patients that could benefit from TACE treatment.http://dx.doi.org/10.1155/2017/4164130 |
| spellingShingle | A. Rebonato L. Graziosi D. Maiettini E. Marino V. De Angelis L. Brunese S. Mosca G. Metro M. Rossi G. Orgera M. Scialpi A. Donini Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Gastroenterology Research and Practice |
| title | Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization |
| title_full | Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization |
| title_fullStr | Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization |
| title_full_unstemmed | Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization |
| title_short | Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization |
| title_sort | inflammatory markers as prognostic factors of survival in patients affected by hepatocellular carcinoma undergoing transarterial chemoembolization |
| url | http://dx.doi.org/10.1155/2017/4164130 |
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