Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review
Butyrate supplementation has gained considerable attention for its potential benefits in livestock, particularly concerning intestinal health and growth performance. This review synthesizes recent research on the diverse roles of butyrate, across various livestock species. As a short-chain fatty aci...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/85 |
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| author | Wenting Chen Qingshan Ma Yan Li Lin Wei Zhenwei Zhang Adnan Khan Muhammad Zahoor Khan Changfa Wang |
| author_facet | Wenting Chen Qingshan Ma Yan Li Lin Wei Zhenwei Zhang Adnan Khan Muhammad Zahoor Khan Changfa Wang |
| author_sort | Wenting Chen |
| collection | DOAJ |
| description | Butyrate supplementation has gained considerable attention for its potential benefits in livestock, particularly concerning intestinal health and growth performance. This review synthesizes recent research on the diverse roles of butyrate, across various livestock species. As a short-chain fatty acid, butyrate is known for enhancing intestinal development, improving immune function, and modulating microbial diversity. Studies indicate that butyrate supports gut barrier integrity, reduces inflammation, and optimizes feed efficiency, especially during the critical weaning and post-weaning periods in calves, piglets, and lambs. Supplementation with butyrate in livestock has been shown to increase average daily gain (ADG), improve gut microbiota balance, promote growth, enhance gut health, boost antioxidant capacity, and reduce diarrhea. Additionally, butyrate plays a role in the epigenetic regulation of gene expression through histone acetylation, influencing tissue development and immune modulation. Its anti-inflammatory and antioxidant effects have been demonstrated across various species, positioning butyrate as a potential therapeutic agent in animal nutrition. This review suggests that optimizing butyrate supplementation strategies to meet the specific needs of each species may yield additional benefits, establishing butyrate as an important dietary additive for enhancing growth performance and health in livestock. |
| format | Article |
| id | doaj-art-d23da494dd29418e821269b8593c5e4a |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-d23da494dd29418e821269b8593c5e4a2025-01-24T13:25:07ZengMDPI AGBiomolecules2218-273X2025-01-011518510.3390/biom15010085Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A ReviewWenting Chen0Qingshan Ma1Yan Li2Lin Wei3Zhenwei Zhang4Adnan Khan5Muhammad Zahoor Khan6Changfa Wang7School of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, ChinaSchool of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, ChinaSchool of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, ChinaSchool of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, ChinaSchool of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, ChinaAnimal Genomics Laboratory, School of Agriculture and Food Science, University College Dublin, D04 V1W8 Dublin, IrelandSchool of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, ChinaSchool of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, ChinaButyrate supplementation has gained considerable attention for its potential benefits in livestock, particularly concerning intestinal health and growth performance. This review synthesizes recent research on the diverse roles of butyrate, across various livestock species. As a short-chain fatty acid, butyrate is known for enhancing intestinal development, improving immune function, and modulating microbial diversity. Studies indicate that butyrate supports gut barrier integrity, reduces inflammation, and optimizes feed efficiency, especially during the critical weaning and post-weaning periods in calves, piglets, and lambs. Supplementation with butyrate in livestock has been shown to increase average daily gain (ADG), improve gut microbiota balance, promote growth, enhance gut health, boost antioxidant capacity, and reduce diarrhea. Additionally, butyrate plays a role in the epigenetic regulation of gene expression through histone acetylation, influencing tissue development and immune modulation. Its anti-inflammatory and antioxidant effects have been demonstrated across various species, positioning butyrate as a potential therapeutic agent in animal nutrition. This review suggests that optimizing butyrate supplementation strategies to meet the specific needs of each species may yield additional benefits, establishing butyrate as an important dietary additive for enhancing growth performance and health in livestock.https://www.mdpi.com/2218-273X/15/1/85butyratelivestockmicrobiotaintestinal healthinflammationantioxidants |
| spellingShingle | Wenting Chen Qingshan Ma Yan Li Lin Wei Zhenwei Zhang Adnan Khan Muhammad Zahoor Khan Changfa Wang Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review Biomolecules butyrate livestock microbiota intestinal health inflammation antioxidants |
| title | Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review |
| title_full | Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review |
| title_fullStr | Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review |
| title_full_unstemmed | Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review |
| title_short | Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review |
| title_sort | butyrate supplementation improves intestinal health and growth performance in livestock a review |
| topic | butyrate livestock microbiota intestinal health inflammation antioxidants |
| url | https://www.mdpi.com/2218-273X/15/1/85 |
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