The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells
The paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplifica...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-08-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/266 |
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| _version_ | 1849399112921776128 |
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| author | D. A. Karseladze I. V. Poddubnaya A. I. Karseladze |
| author_facet | D. A. Karseladze I. V. Poddubnaya A. I. Karseladze |
| author_sort | D. A. Karseladze |
| collection | DOAJ |
| description | The paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplification usually occurs in the tumors responsive to chemotherapy including anthracycline drugs. The altered status of the above genes should be interpreted in the context of aneusomy of chromosomes 7 and 17, on which they are located. No association was found between the pattern of EGFR and TOP IIα gene abnormalities and the basaloid phenotype of BC. |
| format | Article |
| id | doaj-art-d226a0ab29b949969f7a5c70b7014236 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-d226a0ab29b949969f7a5c70b70142362025-08-20T03:38:25ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-08-0104333910.17650/1994-4098-2010-0-4-33-39282The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cellsD. A. Karseladze0I. V. Poddubnaya1A. I. Karseladze2N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesDepartment of Oncology, Russian Medical Academy of Postgraduate Education, Russian Agency for Health CareDepartment for Pathological Anatomy of Human Tumors, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowThe paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplification usually occurs in the tumors responsive to chemotherapy including anthracycline drugs. The altered status of the above genes should be interpreted in the context of aneusomy of chromosomes 7 and 17, on which they are located. No association was found between the pattern of EGFR and TOP IIα gene abnormalities and the basaloid phenotype of BC.https://ojrs.abvpress.ru/ojrs/article/view/266triple-negative breast cancertopoisomerase iiαepidermal growth factor receptoraneusomy of chromosomes 7 and 17 |
| spellingShingle | D. A. Karseladze I. V. Poddubnaya A. I. Karseladze The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells Опухоли женской репродуктивной системы triple-negative breast cancer topoisomerase iiα epidermal growth factor receptor aneusomy of chromosomes 7 and 17 |
| title | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_full | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_fullStr | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_full_unstemmed | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_short | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_sort | status of epidermal growth factor receptor and topoisomerase iiα genes in triple negative breast cancer cells |
| topic | triple-negative breast cancer topoisomerase iiα epidermal growth factor receptor aneusomy of chromosomes 7 and 17 |
| url | https://ojrs.abvpress.ru/ojrs/article/view/266 |
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