Impact of heterogeneity on the dynamics of an SEIR epidemic model

An SEIR epidemic model with an arbitrarily distributed exposed stage is revisited to study the impact of heterogeneity on the spread of infectious diseases. The heterogeneity may come from age or behavior and disease stages, resulting in multi-group and multi-stage models, respectively. For each mod...

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Bibliographic Details
Main Authors: Zhisheng Shuai, P. van den Driessche
Format: Article
Language:English
Published: AIMS Press 2012-02-01
Series:Mathematical Biosciences and Engineering
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Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2012.9.393
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Summary:An SEIR epidemic model with an arbitrarily distributed exposed stage is revisited to study the impact of heterogeneity on the spread of infectious diseases. The heterogeneity may come from age or behavior and disease stages, resulting in multi-group and multi-stage models, respectively. For each model, Lyapunov functionals are used to show that the basic reproduction number $\mathcal{R}_0$ gives a sharp threshold. If $\mathcal{R}_0\leq 1$, then the disease-free equilibrium is globally asymptotically stable and the disease dies out from all groups or stages. If $\mathcal{R}_0>1$, then the disease persists in all groups or stages, and the endemic equilibrium is globally asymptotically stable.
ISSN:1551-0018