Attention-Based Hybrid Deep Learning Models for Classifying COVID-19 Genome Sequences
<b>Background:</b> COVID-19 genetic sequence research is crucial despite immunizations and pandemic control. COVID-19-causing SARS-CoV-2 must be understood genomically for several reasons. New viral strains may resist vaccines. Categorizing genetic sequences helps researchers track chang...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | AI |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-2688/6/1/4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <b>Background:</b> COVID-19 genetic sequence research is crucial despite immunizations and pandemic control. COVID-19-causing SARS-CoV-2 must be understood genomically for several reasons. New viral strains may resist vaccines. Categorizing genetic sequences helps researchers track changes and assess immunization efficacy. Classifying COVID-19 genome sequences with other viruses helps to understand its evolution and interactions with other illnesses. <b>Methods</b>: The proposed study introduces a deep learning-based COVID-19 genomic sequence categorization approach. Attention-based hybrid deep learning (DL) models categorize 1423 COVID-19 and 11,388 other viral genome sequences. An unknown dataset is also used to assess the models. The five models’ accuracy, f1-score, area under the curve (AUC), precision, Matthews correlation coefficient (MCC), and recall are evaluated. <b>Results</b>: The results indicate that the Convolutional neural network (CNN) with Bidirectional long short-term memory (BLSTM) with attention layer (CNN-BLSTM-Att) achieved an accuracy of 99.99%, which outperformed the other models. For external validation, the model shows an accuracy of 99.88%. It reveals that DL-based approaches with an attention layer can accurately classify COVID-19 genomic sequences with a high degree of accuracy. This method might assist in identifying and classifying COVID-19 virus strains in clinical situations. Immunizations have lowered COVID-19 danger, but categorizing its genetic sequences is crucial to global health activities to plan for recurrence or future viral threats. |
|---|---|
| ISSN: | 2673-2688 |