Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study
Background. There is emerging evidence to support the use of granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute ischemic stroke. Aims. To explore feasibility, safety, and preliminary efficacy of G-CSF therapy in patients with acute ischemic stroke. Patients and Method. In r...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.4061/2011/283473 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563182929969152 |
|---|---|
| author | Kameshwar Prasad Amit Kumar Jitendra Kumar Sahu M. V. P. Srivastava Sujata Mohanty Rohit Bhatia Shailesh B. Gaikwad Achal Srivastava Vinay Goyal Manjari Tripathi Chandrashekar Bal Nalini Kant Mishra |
| author_facet | Kameshwar Prasad Amit Kumar Jitendra Kumar Sahu M. V. P. Srivastava Sujata Mohanty Rohit Bhatia Shailesh B. Gaikwad Achal Srivastava Vinay Goyal Manjari Tripathi Chandrashekar Bal Nalini Kant Mishra |
| author_sort | Kameshwar Prasad |
| collection | DOAJ |
| description | Background. There is emerging evidence to support the use of granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute ischemic stroke. Aims. To explore feasibility, safety, and preliminary efficacy of G-CSF therapy in patients with acute ischemic stroke. Patients and Method. In randomized study, 10 patients with acute ischemic stroke were recruited in 1 : 1 ratio to receive 10 μg/kg G-CSF treatment subcutaneously daily for five days with conventional care or conventional treatment alone. Efficacy outcome measures were assessed at baseline, one month, and after six months of treatment included Barthel Index (BI), National Institute of Health Stroke Scale, and modified Rankin Scale. Results. One patient in G-CSF therapy arm died due to raised intracranial pressure. No severe adverse effects were seen in rest of patients receiving G-CSF therapy arm or control arm. No statistically significant difference between intervention and control was observed in any of the scores though a trend of higher improvement of BI score is seen in the intervention group. Conclusion. Although this study did not have power to examine efficacy, it provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy. Further studies need to be done on a large sample to confirm the results. |
| format | Article |
| id | doaj-art-d20692ef064546f79d311f3c0a27c1ef |
| institution | Kabale University |
| issn | 2042-0056 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-d20692ef064546f79d311f3c0a27c1ef2025-02-03T01:20:46ZengWileyStroke Research and Treatment2042-00562011-01-01201110.4061/2011/283473283473Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot StudyKameshwar Prasad0Amit Kumar1Jitendra Kumar Sahu2M. V. P. Srivastava3Sujata Mohanty4Rohit Bhatia5Shailesh B. Gaikwad6Achal Srivastava7Vinay Goyal8Manjari Tripathi9Chandrashekar Bal10Nalini Kant Mishra11Department of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaStem Cell Facility, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Neuro-Radiology, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Neuro-Radiology, All India Institute of Medical Sciences, New Delhi 110029, IndiaBackground. There is emerging evidence to support the use of granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute ischemic stroke. Aims. To explore feasibility, safety, and preliminary efficacy of G-CSF therapy in patients with acute ischemic stroke. Patients and Method. In randomized study, 10 patients with acute ischemic stroke were recruited in 1 : 1 ratio to receive 10 μg/kg G-CSF treatment subcutaneously daily for five days with conventional care or conventional treatment alone. Efficacy outcome measures were assessed at baseline, one month, and after six months of treatment included Barthel Index (BI), National Institute of Health Stroke Scale, and modified Rankin Scale. Results. One patient in G-CSF therapy arm died due to raised intracranial pressure. No severe adverse effects were seen in rest of patients receiving G-CSF therapy arm or control arm. No statistically significant difference between intervention and control was observed in any of the scores though a trend of higher improvement of BI score is seen in the intervention group. Conclusion. Although this study did not have power to examine efficacy, it provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy. Further studies need to be done on a large sample to confirm the results.http://dx.doi.org/10.4061/2011/283473 |
| spellingShingle | Kameshwar Prasad Amit Kumar Jitendra Kumar Sahu M. V. P. Srivastava Sujata Mohanty Rohit Bhatia Shailesh B. Gaikwad Achal Srivastava Vinay Goyal Manjari Tripathi Chandrashekar Bal Nalini Kant Mishra Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study Stroke Research and Treatment |
| title | Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study |
| title_full | Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study |
| title_fullStr | Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study |
| title_full_unstemmed | Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study |
| title_short | Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study |
| title_sort | mobilization of stem cells using g csf for acute ischemic stroke a randomized controlled pilot study |
| url | http://dx.doi.org/10.4061/2011/283473 |
| work_keys_str_mv | AT kameshwarprasad mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT amitkumar mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT jitendrakumarsahu mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT mvpsrivastava mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT sujatamohanty mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT rohitbhatia mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT shaileshbgaikwad mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT achalsrivastava mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT vinaygoyal mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT manjaritripathi mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT chandrashekarbal mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy AT nalinikantmishra mobilizationofstemcellsusinggcsfforacuteischemicstrokearandomizedcontrolledpilotstudy |