Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse
The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. NMDA receptor-mediated currents, apart from their Ca2+ permeability, show a...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.1998.8 |
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| _version_ | 1832556983627022336 |
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| author | Egidio D'Angelo Paola Rossi |
| author_facet | Egidio D'Angelo Paola Rossi |
| author_sort | Egidio D'Angelo |
| collection | DOAJ |
| description | The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. NMDA receptor-mediated currents, apart from their Ca2+
permeability, show a marked voltage dependence, consisting of current increase and slowdown during membrane depolarization. During highfrequency synaptic transmission, NMDA current increase and slowdown are primed by non-NMDA receptor-dependent depolarization and proceed regeneratively. Thus, NMDA receptors make a decisive contribution to membrane depolarization and spike-firing. From the data obtained at the mossy fiber- granule cell synapse of the cerebellum, we propose that the electrogenic role of NMDA receptors is functional to LTP induction. Moreover, during LTP, both NMDA and non- NMDA receptor currents are potentiated, thus establishing a feed-forward mechanism that ultimately enhances spike firing. Thus, NMDA receptors exert an integrated control on signal coding and plasticity. This mechanism may have important implications for information processing at the cerebellar mossy fibergranule cell relay. |
| format | Article |
| id | doaj-art-d20586a2ab554bd290df251637839b95 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d20586a2ab554bd290df251637839b952025-02-03T05:43:59ZengWileyNeural Plasticity2090-59041687-54431998-01-016381610.1155/NP.1998.8Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central SynapseEgidio D'Angelo0Paola Rossi1Istituto di Fisiologia Generale, and lstituto Nazionale Fisica della Materia (INFM), Pavia Unit, Via Forlanini 6, Pavia I-27100, ItalyIstituto di Fisiologia Generale, and lstituto Nazionale Fisica della Materia (INFM), Pavia Unit, Via Forlanini 6, Pavia I-27100, ItalyThe role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. NMDA receptor-mediated currents, apart from their Ca2+ permeability, show a marked voltage dependence, consisting of current increase and slowdown during membrane depolarization. During highfrequency synaptic transmission, NMDA current increase and slowdown are primed by non-NMDA receptor-dependent depolarization and proceed regeneratively. Thus, NMDA receptors make a decisive contribution to membrane depolarization and spike-firing. From the data obtained at the mossy fiber- granule cell synapse of the cerebellum, we propose that the electrogenic role of NMDA receptors is functional to LTP induction. Moreover, during LTP, both NMDA and non- NMDA receptor currents are potentiated, thus establishing a feed-forward mechanism that ultimately enhances spike firing. Thus, NMDA receptors exert an integrated control on signal coding and plasticity. This mechanism may have important implications for information processing at the cerebellar mossy fibergranule cell relay.http://dx.doi.org/10.1155/NP.1998.8 |
| spellingShingle | Egidio D'Angelo Paola Rossi Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse Neural Plasticity |
| title | Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse |
| title_full | Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse |
| title_fullStr | Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse |
| title_full_unstemmed | Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse |
| title_short | Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse |
| title_sort | integrated regulation of signal coding and plasticity by nmda receptors at a central synapse |
| url | http://dx.doi.org/10.1155/NP.1998.8 |
| work_keys_str_mv | AT egidiodangelo integratedregulationofsignalcodingandplasticitybynmdareceptorsatacentralsynapse AT paolarossi integratedregulationofsignalcodingandplasticitybynmdareceptorsatacentralsynapse |