Colistin: The phoenix Arises
The polymyxins were discovered in the 1940s and represent a group of closely related polypeptide antibiotics obtained from Bacillus polymyxa, which was originally isolated from soil (1,2). Although they have been used extensively worldwide in topical otic and ophthalmic solutions for decades, the in...
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| Format: | Article |
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Wiley
2006-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2006/901873 |
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| author | JM Conly BL Johnston |
| author_facet | JM Conly BL Johnston |
| author_sort | JM Conly |
| collection | DOAJ |
| description | The polymyxins were discovered in the 1940s and represent a group of closely related polypeptide antibiotics obtained from Bacillus polymyxa, which was originally isolated from soil (1,2). Although they have been used extensively worldwide in topical otic and ophthalmic solutions for decades, the intravenous formulations were gradually abandoned in most parts of the world in the early 1980s because of the reported high incidence of nephrotoxicity (3-5). As a result, the use of polymyxin preparations has been mainly restricted to the treatment of lung infections due to multidrug-resistant (MDR) gram-negative bacteria in patients with cystic fibrosis (6,7). The emergence of bacteria resistant to most classes of commercially available antibiotics and the shortage of novel antimicrobial agents with activity against gram-negative microorganisms have led to the reemergence of polymyxins as a valuable addition to the therapeutic armamentarium. It was thus considered timely to review colistin and its emerging role in managing infections due to MDR gram-negative bacteria. |
| format | Article |
| id | doaj-art-d201fbabf055435887c6d6255b1c0aca |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-d201fbabf055435887c6d6255b1c0aca2025-02-03T01:24:40ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322006-01-0117526726910.1155/2006/901873Colistin: The phoenix ArisesJM Conly0BL Johnston1Departments of Pathology and Laboratory Medicine, Medicine, and Microbiology and Infectious Diseases, Centre for Antimicrobial Resistance, University of Calgary, Calgary, Alberta, CanadaQueen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, CanadaThe polymyxins were discovered in the 1940s and represent a group of closely related polypeptide antibiotics obtained from Bacillus polymyxa, which was originally isolated from soil (1,2). Although they have been used extensively worldwide in topical otic and ophthalmic solutions for decades, the intravenous formulations were gradually abandoned in most parts of the world in the early 1980s because of the reported high incidence of nephrotoxicity (3-5). As a result, the use of polymyxin preparations has been mainly restricted to the treatment of lung infections due to multidrug-resistant (MDR) gram-negative bacteria in patients with cystic fibrosis (6,7). The emergence of bacteria resistant to most classes of commercially available antibiotics and the shortage of novel antimicrobial agents with activity against gram-negative microorganisms have led to the reemergence of polymyxins as a valuable addition to the therapeutic armamentarium. It was thus considered timely to review colistin and its emerging role in managing infections due to MDR gram-negative bacteria.http://dx.doi.org/10.1155/2006/901873 |
| spellingShingle | JM Conly BL Johnston Colistin: The phoenix Arises Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Colistin: The phoenix Arises |
| title_full | Colistin: The phoenix Arises |
| title_fullStr | Colistin: The phoenix Arises |
| title_full_unstemmed | Colistin: The phoenix Arises |
| title_short | Colistin: The phoenix Arises |
| title_sort | colistin the phoenix arises |
| url | http://dx.doi.org/10.1155/2006/901873 |
| work_keys_str_mv | AT jmconly colistinthephoenixarises AT bljohnston colistinthephoenixarises |