Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections
Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal pathogens, are able to cause disease in immunocompetent individuals. They infect keratinized tissue such as skin, hair, and nails, resulting in tinea infections, including ringworm. Little is known about the molecu...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/358305 |
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| _version_ | 1832560834505605120 |
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| author | Rebecca Rashid Achterman Theodore C. White |
| author_facet | Rebecca Rashid Achterman Theodore C. White |
| author_sort | Rebecca Rashid Achterman |
| collection | DOAJ |
| description | Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal pathogens, are able to cause disease in immunocompetent individuals. They infect keratinized tissue such as skin, hair, and nails, resulting in tinea infections, including ringworm. Little is known about the molecular mechanisms that underlie the ability of these organisms to establish and maintain infection. The recent availability of genome sequence information and improved genetic manipulation have enabled researchers to begin to identify and study the role of virulence factors of dermatophytes. This paper will summarize our current understanding of dermatophyte virulence factors and discuss future directions for identifying and testing virulence factors. |
| format | Article |
| id | doaj-art-d1fc2973d574457db72136ab98ef41bb |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-d1fc2973d574457db72136ab98ef41bb2025-02-03T01:26:43ZengWileyInternational Journal of Microbiology1687-918X1687-91982012-01-01201210.1155/2012/358305358305Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin InfectionsRebecca Rashid Achterman0Theodore C. White1Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109-5219, USASeattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109-5219, USADermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal pathogens, are able to cause disease in immunocompetent individuals. They infect keratinized tissue such as skin, hair, and nails, resulting in tinea infections, including ringworm. Little is known about the molecular mechanisms that underlie the ability of these organisms to establish and maintain infection. The recent availability of genome sequence information and improved genetic manipulation have enabled researchers to begin to identify and study the role of virulence factors of dermatophytes. This paper will summarize our current understanding of dermatophyte virulence factors and discuss future directions for identifying and testing virulence factors.http://dx.doi.org/10.1155/2012/358305 |
| spellingShingle | Rebecca Rashid Achterman Theodore C. White Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections International Journal of Microbiology |
| title | Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections |
| title_full | Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections |
| title_fullStr | Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections |
| title_full_unstemmed | Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections |
| title_short | Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections |
| title_sort | dermatophyte virulence factors identifying and analyzing genes that may contribute to chronic or acute skin infections |
| url | http://dx.doi.org/10.1155/2012/358305 |
| work_keys_str_mv | AT rebeccarashidachterman dermatophytevirulencefactorsidentifyingandanalyzinggenesthatmaycontributetochronicoracuteskininfections AT theodorecwhite dermatophytevirulencefactorsidentifyingandanalyzinggenesthatmaycontributetochronicoracuteskininfections |