Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches
Sarcopenia is an age-related condition characterized by the progressive loss of skeletal muscle mass and strength. With the global aging population, its incidence is rapidly increasing. Lipid peroxidation is a critical biochemical process that generates reactive oxygen species (ROS), leading to the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1525205/full |
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| author | Yifan Lu Yifan Lu Tiao Li Yang Shu Yang Shu Chengyin Lu Chengyin Lu Zhiqiang Luo Zhiqiang Luo Jingrui Wang Jingrui Wang Hui Xiong Wangyang Li Wangyang Li |
| author_facet | Yifan Lu Yifan Lu Tiao Li Yang Shu Yang Shu Chengyin Lu Chengyin Lu Zhiqiang Luo Zhiqiang Luo Jingrui Wang Jingrui Wang Hui Xiong Wangyang Li Wangyang Li |
| author_sort | Yifan Lu |
| collection | DOAJ |
| description | Sarcopenia is an age-related condition characterized by the progressive loss of skeletal muscle mass and strength. With the global aging population, its incidence is rapidly increasing. Lipid peroxidation is a critical biochemical process that generates reactive oxygen species (ROS), leading to the destruction of muscle cell structure and function. It plays a pivotal role in the onset and progression of sarcopenia. This review summarizes the mechanisms by which lipid peroxidation contributes to sarcopenia, with a focus on its regulatory effects on cell membrane damage, mitochondrial dysfunction, and cell death. In addition, we discuss the protective role of antioxidant factors such as GPX4 (glutathione peroxidase 4) and antioxidant peptides like SS peptides in mitigating lipid peroxidation and delaying the progression of sarcopenia. Finally, the potential of various strategies, including natural compounds, supplements, natural extracts, and lifestyle interventions, in inhibiting lipid peroxidation and promoting muscle health is explored. |
| format | Article |
| id | doaj-art-d1ef1b84fc5c4e91b910b8e1394bb681 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-d1ef1b84fc5c4e91b910b8e1394bb6812025-02-03T11:55:22ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15252051525205Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approachesYifan Lu0Yifan Lu1Tiao Li2Yang Shu3Yang Shu4Chengyin Lu5Chengyin Lu6Zhiqiang Luo7Zhiqiang Luo8Jingrui Wang9Jingrui Wang10Hui Xiong11Wangyang Li12Wangyang Li13Department of Orthopedics, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Graduate School, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Graduate School, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Graduate School, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Graduate School, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Graduate School, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Graduate School, Hunan University of Chinese Medicine, Changsha, ChinaSarcopenia is an age-related condition characterized by the progressive loss of skeletal muscle mass and strength. With the global aging population, its incidence is rapidly increasing. Lipid peroxidation is a critical biochemical process that generates reactive oxygen species (ROS), leading to the destruction of muscle cell structure and function. It plays a pivotal role in the onset and progression of sarcopenia. This review summarizes the mechanisms by which lipid peroxidation contributes to sarcopenia, with a focus on its regulatory effects on cell membrane damage, mitochondrial dysfunction, and cell death. In addition, we discuss the protective role of antioxidant factors such as GPX4 (glutathione peroxidase 4) and antioxidant peptides like SS peptides in mitigating lipid peroxidation and delaying the progression of sarcopenia. Finally, the potential of various strategies, including natural compounds, supplements, natural extracts, and lifestyle interventions, in inhibiting lipid peroxidation and promoting muscle health is explored.https://www.frontiersin.org/articles/10.3389/fmed.2025.1525205/fullsarcopenialipid peroxidationoxidative stressantioxidantstherapeutic strategies |
| spellingShingle | Yifan Lu Yifan Lu Tiao Li Yang Shu Yang Shu Chengyin Lu Chengyin Lu Zhiqiang Luo Zhiqiang Luo Jingrui Wang Jingrui Wang Hui Xiong Wangyang Li Wangyang Li Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches Frontiers in Medicine sarcopenia lipid peroxidation oxidative stress antioxidants therapeutic strategies |
| title | Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches |
| title_full | Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches |
| title_fullStr | Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches |
| title_full_unstemmed | Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches |
| title_short | Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches |
| title_sort | lipid peroxidation and sarcopenia molecular mechanisms and potential therapeutic approaches |
| topic | sarcopenia lipid peroxidation oxidative stress antioxidants therapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1525205/full |
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