Effects of Carbon Dioxide Therapy on Skin Wound Healing
Promoting rapid healing is a concern in skin wound treatment, as the increased pain and the loss of functional ability when wounds become chronic create a complex problem to manage. This scoping review aimed to explore the literature and synthesize existing knowledge on the therapeutic use of CO<...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/228 |
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| author | José Prazeres Ana Lima Gesiane Ribeiro |
| author_facet | José Prazeres Ana Lima Gesiane Ribeiro |
| author_sort | José Prazeres |
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| description | Promoting rapid healing is a concern in skin wound treatment, as the increased pain and the loss of functional ability when wounds become chronic create a complex problem to manage. This scoping review aimed to explore the literature and synthesize existing knowledge on the therapeutic use of CO<sub>2</sub> in treating cutaneous wounds. The literature was selected using previously defined inclusion and exclusion criteria, and 22 articles were selected for data extraction. The most researched type of injury was chronic wounds located on the extremities of the limbs. Carboxytherapy was performed in five different ways: subcutaneous, intradermal, or intralesional injections; in hot water baths with temperatures ranging from 30 to 42 °C; transcutaneous application; intra-abdominal insufflation; and a paste for transcutaneous local application. The main effects of CO<sub>2</sub> therapy described were as follows: improved blood flow and local oxygenation, reduction of the inflammatory process, increased collagen production, and improved clinical aspects of wounds, with faster healing. Carboxytherapy can be considered a good alternative for treating skin wounds, although further studies should be pursued to elucidate its molecular mechanisms and enhance its efficacy. |
| format | Article |
| id | doaj-art-d1eed793c5724191a0bab8bed4f2f81c |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Biomedicines |
| spelling | doaj-art-d1eed793c5724191a0bab8bed4f2f81c2025-01-24T13:24:28ZengMDPI AGBiomedicines2227-90592025-01-0113122810.3390/biomedicines13010228Effects of Carbon Dioxide Therapy on Skin Wound HealingJosé Prazeres0Ana Lima1Gesiane Ribeiro2I-MVET Research in Veterinary Medicine, Faculty of Veterinary Medicine, Lusófona University—Lisbon University Centre, 1749-024 Lisbon, PortugalI-MVET Research in Veterinary Medicine, Faculty of Veterinary Medicine, Lusófona University—Lisbon University Centre, 1749-024 Lisbon, PortugalI-MVET Research in Veterinary Medicine, Faculty of Veterinary Medicine, Lusófona University—Lisbon University Centre, 1749-024 Lisbon, PortugalPromoting rapid healing is a concern in skin wound treatment, as the increased pain and the loss of functional ability when wounds become chronic create a complex problem to manage. This scoping review aimed to explore the literature and synthesize existing knowledge on the therapeutic use of CO<sub>2</sub> in treating cutaneous wounds. The literature was selected using previously defined inclusion and exclusion criteria, and 22 articles were selected for data extraction. The most researched type of injury was chronic wounds located on the extremities of the limbs. Carboxytherapy was performed in five different ways: subcutaneous, intradermal, or intralesional injections; in hot water baths with temperatures ranging from 30 to 42 °C; transcutaneous application; intra-abdominal insufflation; and a paste for transcutaneous local application. The main effects of CO<sub>2</sub> therapy described were as follows: improved blood flow and local oxygenation, reduction of the inflammatory process, increased collagen production, and improved clinical aspects of wounds, with faster healing. Carboxytherapy can be considered a good alternative for treating skin wounds, although further studies should be pursued to elucidate its molecular mechanisms and enhance its efficacy.https://www.mdpi.com/2227-9059/13/1/228carbon dioxideCO<sub>2</sub>carboxytherapyhealingskinwound |
| spellingShingle | José Prazeres Ana Lima Gesiane Ribeiro Effects of Carbon Dioxide Therapy on Skin Wound Healing Biomedicines carbon dioxide CO<sub>2</sub> carboxytherapy healing skin wound |
| title | Effects of Carbon Dioxide Therapy on Skin Wound Healing |
| title_full | Effects of Carbon Dioxide Therapy on Skin Wound Healing |
| title_fullStr | Effects of Carbon Dioxide Therapy on Skin Wound Healing |
| title_full_unstemmed | Effects of Carbon Dioxide Therapy on Skin Wound Healing |
| title_short | Effects of Carbon Dioxide Therapy on Skin Wound Healing |
| title_sort | effects of carbon dioxide therapy on skin wound healing |
| topic | carbon dioxide CO<sub>2</sub> carboxytherapy healing skin wound |
| url | https://www.mdpi.com/2227-9059/13/1/228 |
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