The Interplay between the Bone and the Immune System
In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and mye...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/720504 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558203296022528 |
|---|---|
| author | Giorgio Mori Patrizia D'Amelio Roberta Faccio Giacomina Brunetti |
| author_facet | Giorgio Mori Patrizia D'Amelio Roberta Faccio Giacomina Brunetti |
| author_sort | Giorgio Mori |
| collection | DOAJ |
| description | In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells. On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts. This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field. Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells. |
| format | Article |
| id | doaj-art-d1edd6408f5d4549b0219d95e700c484 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d1edd6408f5d4549b0219d95e700c4842025-02-03T01:33:06ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/720504720504The Interplay between the Bone and the Immune SystemGiorgio Mori0Patrizia D'Amelio1Roberta Faccio2Giacomina Brunetti3Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Medical Sciences, University of Torino, 10126 Torino, ItalyDepartment of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare, 11, 70124 Bari, ItalyIn the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells. On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts. This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field. Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells.http://dx.doi.org/10.1155/2013/720504 |
| spellingShingle | Giorgio Mori Patrizia D'Amelio Roberta Faccio Giacomina Brunetti The Interplay between the Bone and the Immune System Clinical and Developmental Immunology |
| title | The Interplay between the Bone and the Immune System |
| title_full | The Interplay between the Bone and the Immune System |
| title_fullStr | The Interplay between the Bone and the Immune System |
| title_full_unstemmed | The Interplay between the Bone and the Immune System |
| title_short | The Interplay between the Bone and the Immune System |
| title_sort | interplay between the bone and the immune system |
| url | http://dx.doi.org/10.1155/2013/720504 |
| work_keys_str_mv | AT giorgiomori theinterplaybetweentheboneandtheimmunesystem AT patriziadamelio theinterplaybetweentheboneandtheimmunesystem AT robertafaccio theinterplaybetweentheboneandtheimmunesystem AT giacominabrunetti theinterplaybetweentheboneandtheimmunesystem AT giorgiomori interplaybetweentheboneandtheimmunesystem AT patriziadamelio interplaybetweentheboneandtheimmunesystem AT robertafaccio interplaybetweentheboneandtheimmunesystem AT giacominabrunetti interplaybetweentheboneandtheimmunesystem |