Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here, we show that ple...

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Main Authors: Zuzana Outla, Gizem Oyman-Eyrilmez, Katerina Korelova, Magdalena Prechova, Lukas Frick, Lenka Sarnova, Piyush Bisht, Petra Novotna, Jan Kosla, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Mohammad Rahbari, Nuh Rahbari, Emrullah Birgin, Bibiana Kvasnicova, Andrea Galisova, Katerina Sulkova, Andreas Bauer, Njainday Jobe, Ondrej Tolde, Eva Sticova, Daniel Rösel, Tracy O'Connor, Martin Otahal, Daniel Jirak, Mathias Heikenwälder, Gerhard Wiche, Samuel M Meier-Menches, Martin Gregor
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
plectin
hepatocellular carcinoma
cytoskeletal crosstalk
plecstatin
metastasis
therapeutic strategy
Online Access:https://elifesciences.org/articles/102205
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