Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case–control study with MDM2/CDK4 immunostaining and MDM2/CDK4 fluorescence in situ hybridization

Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case–control study with MDM2/CDK4 immunostaining and MDM2/CDK4 fluorescence in situ hybridization

Abstract Background Lipomatous tumors represent the most common type of soft tissue neoplasms. Mouse double minute 2 homolog (MDM2)/cyclin-dependent kinase 4 (CDK4) immunostaining is considered effective in differentiating between benign lipomas and intermediate malignant atypical lipomatous tumors/...

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Bibliographic Details
Main Authors: Kentaro Nomura, Masato Tomita, Kishio Kuroda, Masakazu Souda, Ko Chiba, Akihiko Yonekura, Makoto Osaki
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Cancer
Subjects:
Atypical lipomatous tumor
Lipoma
FISH
Immunohistochemistry
MDM2
CDK4
Online Access:https://doi.org/10.1186/s12885-024-13215-4
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