Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program
Substance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, significant gaps remain in our understanding of EFs in SUDs, including the dimensional relations...
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2025-05-01
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| author | Yuliya S. Nikolova Yuliya S. Nikolova Yuliya S. Nikolova Anthony C. Ruocco Anthony C. Ruocco Anthony C. Ruocco Anthony C. Ruocco Daniel Felsky Daniel Felsky Daniel Felsky Shannon Lange Shannon Lange Shannon Lange Shannon Lange Thomas D. Prevot Thomas D. Prevot Thomas D. Prevot Erica Vieira Erica Vieira Daphne Voineskos Daphne Voineskos Jeffrey D. Wardell Jeffrey D. Wardell Jeffrey D. Wardell Jeffrey D. Wardell Daniel M. Blumberger Daniel M. Blumberger Kevan Clifford Kevan Clifford Ravinder Naik Dharavath Philip Gerretsen Philip Gerretsen Ahmed N. Hassan Ahmed N. Hassan Ingrid M. Hope Samantha H. Irwin Sheila K. Jennings Sheila K. Jennings Bernard Le Foll Bernard Le Foll Osnat Melamed Osnat Melamed Josh Orson Peter Pangarov Leanne Quigley Cayley Russell Kevin Shield Kevin Shield Kevin Shield Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Ashley Smoke Ashley Smoke Victor Tang Victor Tang Victor Tang Diana Valdes Cabrera Diana Valdes Cabrera Wei Wang Samantha Wells Samantha Wells Samantha Wells Rajith Wickramatunga Etienne Sibille Etienne Sibille Etienne Sibille Lena C. Quilty Lena C. Quilty |
| author_facet | Yuliya S. Nikolova Yuliya S. Nikolova Yuliya S. Nikolova Anthony C. Ruocco Anthony C. Ruocco Anthony C. Ruocco Anthony C. Ruocco Daniel Felsky Daniel Felsky Daniel Felsky Shannon Lange Shannon Lange Shannon Lange Shannon Lange Thomas D. Prevot Thomas D. Prevot Thomas D. Prevot Erica Vieira Erica Vieira Daphne Voineskos Daphne Voineskos Jeffrey D. Wardell Jeffrey D. Wardell Jeffrey D. Wardell Jeffrey D. Wardell Daniel M. Blumberger Daniel M. Blumberger Kevan Clifford Kevan Clifford Ravinder Naik Dharavath Philip Gerretsen Philip Gerretsen Ahmed N. Hassan Ahmed N. Hassan Ingrid M. Hope Samantha H. Irwin Sheila K. Jennings Sheila K. Jennings Bernard Le Foll Bernard Le Foll Osnat Melamed Osnat Melamed Josh Orson Peter Pangarov Leanne Quigley Cayley Russell Kevin Shield Kevin Shield Kevin Shield Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Ashley Smoke Ashley Smoke Victor Tang Victor Tang Victor Tang Diana Valdes Cabrera Diana Valdes Cabrera Wei Wang Samantha Wells Samantha Wells Samantha Wells Rajith Wickramatunga Etienne Sibille Etienne Sibille Etienne Sibille Lena C. Quilty Lena C. Quilty |
| author_sort | Yuliya S. Nikolova |
| collection | DOAJ |
| description | Substance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, significant gaps remain in our understanding of EFs in SUDs, including the dimensional relationships of EFs to underlying neural circuits, molecular biomarkers, disorder heterogeneity, and functional ability. Transforming health outcomes for people with SUDs requires an integration of clinical, biomedical, preclinical, and health services research. Through such interdisciplinary research, we can develop policies and interventions that align with biopsychosocial models of addiction, addressing the complex cognitive concerns of people with SUDs in a more holistic and effective way. Here, we introduce the design and procedures underlying Cognitive Dysfunction in the Addictions (CDiA), an integrative research program, which aims to fill these knowledge gaps and facilitate research discoveries to enhance treatments for people living with SUDs. The CDiA Program comprises seven interdisciplinary projects that aim to evaluate the central thesis that EF has a crucial role in functional outcomes in SUDs. The projects draw on a diverse sample of adults aged 18-60 (target N=400) seeking treatment for SUD, who are followed over one year to identify specific EF domains most associated with improved functioning. Projects 1-3 investigate SUD symptoms, brain circuits, and blood biomarkers and their associations with key EF domains (inhibition, working memory, and set-shifting) and functional outcomes (disability, quality of life). Projects 4 and 5 evaluate interventions for SUDs and their impacts on EF: a clinical trial of repetitive transcranial magnetic stimulation and a preclinical study of potential new pharmacological treatments in rodents. Project 6 links EF to healthcare utilization and is supplemented with a qualitative investigation of EF-related barriers to treatment engagement. Project 7 uses whole-person modeling to integrate the multi-modal data generated across projects, applying clustering and deep learning methods to identify patient subtypes and drive future cross-disciplinary initiatives. The CDiA Program will bring scientific domains together to uncover novel ways in which EFs are linked to SUD severity and functional recovery, and facilitate future discoveries to improve health outcomes in individuals living with SUDs. |
| format | Article |
| id | doaj-art-d1ddab4baaec42e6bd77340215bc2cdb |
| institution | DOAJ |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-d1ddab4baaec42e6bd77340215bc2cdb2025-08-20T03:07:23ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-05-011610.3389/fpsyt.2025.14559681455968Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research programYuliya S. Nikolova0Yuliya S. Nikolova1Yuliya S. Nikolova2Anthony C. Ruocco3Anthony C. Ruocco4Anthony C. Ruocco5Anthony C. Ruocco6Daniel Felsky7Daniel Felsky8Daniel Felsky9Shannon Lange10Shannon Lange11Shannon Lange12Shannon Lange13Thomas D. Prevot14Thomas D. Prevot15Thomas D. Prevot16Erica Vieira17Erica Vieira18Daphne Voineskos19Daphne Voineskos20Jeffrey D. Wardell21Jeffrey D. Wardell22Jeffrey D. Wardell23Jeffrey D. Wardell24Daniel M. Blumberger25Daniel M. Blumberger26Kevan Clifford27Kevan Clifford28Ravinder Naik Dharavath29Philip Gerretsen30Philip Gerretsen31Ahmed N. Hassan32Ahmed N. Hassan33Ingrid M. Hope34Samantha H. Irwin35Sheila K. Jennings36Sheila K. Jennings37Bernard Le Foll38Bernard Le Foll39Osnat Melamed40Osnat Melamed41Josh Orson42Peter Pangarov43Leanne Quigley44Cayley Russell45Kevin Shield46Kevin Shield47Kevin Shield48Matthew E. Sloan49Matthew E. Sloan50Matthew E. Sloan51Matthew E. Sloan52Matthew E. Sloan53Ashley Smoke54Ashley Smoke55Victor Tang56Victor Tang57Victor Tang58Diana Valdes Cabrera59Diana Valdes Cabrera60Wei Wang61Samantha Wells62Samantha Wells63Samantha Wells64Rajith Wickramatunga65Etienne Sibille66Etienne Sibille67Etienne Sibille68Lena C. Quilty69Lena C. Quilty70Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaDepartment of Psychological Clinical Science, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaDepartment of Psychological Clinical Science, University of Toronto, Toronto, ON, CanadaDepartment of Psychology, University of Toronto Scarborough, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaDivision of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaInstitute of Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaDepartment of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaInstitute of Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychology, York University, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada0Moms Stop the Harm, Victoria, BC, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada1Department of Family and Community Medicine, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada2Ferkauf Graduate School of Psychology, Yeshiva University, New York, NY, United States3Ontario Canadian Research Initiative in Substance Matters (CRISM) Node Team, Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada4Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaDepartment of Psychological Clinical Science, University of Toronto, Toronto, ON, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada5The Ontario Network of People Who Use Drugs, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada6Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada7Department of Epidemiology and Biostatistics, Western University, London, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaDepartment of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, CanadaSubstance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, significant gaps remain in our understanding of EFs in SUDs, including the dimensional relationships of EFs to underlying neural circuits, molecular biomarkers, disorder heterogeneity, and functional ability. Transforming health outcomes for people with SUDs requires an integration of clinical, biomedical, preclinical, and health services research. Through such interdisciplinary research, we can develop policies and interventions that align with biopsychosocial models of addiction, addressing the complex cognitive concerns of people with SUDs in a more holistic and effective way. Here, we introduce the design and procedures underlying Cognitive Dysfunction in the Addictions (CDiA), an integrative research program, which aims to fill these knowledge gaps and facilitate research discoveries to enhance treatments for people living with SUDs. The CDiA Program comprises seven interdisciplinary projects that aim to evaluate the central thesis that EF has a crucial role in functional outcomes in SUDs. The projects draw on a diverse sample of adults aged 18-60 (target N=400) seeking treatment for SUD, who are followed over one year to identify specific EF domains most associated with improved functioning. Projects 1-3 investigate SUD symptoms, brain circuits, and blood biomarkers and their associations with key EF domains (inhibition, working memory, and set-shifting) and functional outcomes (disability, quality of life). Projects 4 and 5 evaluate interventions for SUDs and their impacts on EF: a clinical trial of repetitive transcranial magnetic stimulation and a preclinical study of potential new pharmacological treatments in rodents. Project 6 links EF to healthcare utilization and is supplemented with a qualitative investigation of EF-related barriers to treatment engagement. Project 7 uses whole-person modeling to integrate the multi-modal data generated across projects, applying clustering and deep learning methods to identify patient subtypes and drive future cross-disciplinary initiatives. The CDiA Program will bring scientific domains together to uncover novel ways in which EFs are linked to SUD severity and functional recovery, and facilitate future discoveries to improve health outcomes in individuals living with SUDs.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1455968/fullalcohol use disordersubstance use disorderaddictioncognitionexecutive functionpreclinical |
| spellingShingle | Yuliya S. Nikolova Yuliya S. Nikolova Yuliya S. Nikolova Anthony C. Ruocco Anthony C. Ruocco Anthony C. Ruocco Anthony C. Ruocco Daniel Felsky Daniel Felsky Daniel Felsky Shannon Lange Shannon Lange Shannon Lange Shannon Lange Thomas D. Prevot Thomas D. Prevot Thomas D. Prevot Erica Vieira Erica Vieira Daphne Voineskos Daphne Voineskos Jeffrey D. Wardell Jeffrey D. Wardell Jeffrey D. Wardell Jeffrey D. Wardell Daniel M. Blumberger Daniel M. Blumberger Kevan Clifford Kevan Clifford Ravinder Naik Dharavath Philip Gerretsen Philip Gerretsen Ahmed N. Hassan Ahmed N. Hassan Ingrid M. Hope Samantha H. Irwin Sheila K. Jennings Sheila K. Jennings Bernard Le Foll Bernard Le Foll Osnat Melamed Osnat Melamed Josh Orson Peter Pangarov Leanne Quigley Cayley Russell Kevin Shield Kevin Shield Kevin Shield Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Matthew E. Sloan Ashley Smoke Ashley Smoke Victor Tang Victor Tang Victor Tang Diana Valdes Cabrera Diana Valdes Cabrera Wei Wang Samantha Wells Samantha Wells Samantha Wells Rajith Wickramatunga Etienne Sibille Etienne Sibille Etienne Sibille Lena C. Quilty Lena C. Quilty Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program Frontiers in Psychiatry alcohol use disorder substance use disorder addiction cognition executive function preclinical |
| title | Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program |
| title_full | Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program |
| title_fullStr | Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program |
| title_full_unstemmed | Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program |
| title_short | Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program |
| title_sort | cognitive dysfunction in the addictions cdia protocol for a neuron to neighbourhood collaborative research program |
| topic | alcohol use disorder substance use disorder addiction cognition executive function preclinical |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1455968/full |
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