Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA

Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA

Mismatched T:G base pairs can arise during de novo replication as well as base excision repair (BER). In particular, the action of the gap-filling polymerase β (Polβ) can generate a T:G pair as well as a nick in the DNA backbone. The processing of a nicked T:G mispair is poorly understood. We are in...

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Bibliographic Details
Main Authors: Hala Ouzon-Shubeita, Rebecca Barnes, Lillian F. Schmaltz, Seongmin Lee
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
DNA damage
DNA glycosylase
mismatch
Online Access:https://www.mdpi.com/1420-3049/30/9/2083
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