Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway

Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway

BackgroundNeuronal senescence is a common pathological feature of various neurodegenerative diseases, with ferroptosis playing a significant role. This study aims to investigate the role of ErbB4 receptor activation in preventing D-Galactose (D-gal)-induced neuronal senescence.MethodsMice subjected...

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Bibliographic Details
Main Authors: Ji-Ji Dao, Wei Zhang, Chong Liu, Qian Li, Chen-Meng Qiao, Chun Cui, Yan-Qin Shen, Shuang-Xi Chen, Wei-Jiang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
ErbB4 receptor
small molecule
senescence
D-galactose
hippocampus
neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1528604/full
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