Production of platelets <i>in vitro</i> in functionalised 3-dimensional scaffolds mimicking the bone marrow niche

Production of platelets <i>in vitro</i> in functionalised 3-dimensional scaffolds mimicking the bone marrow niche

The safety, quality and supply of donor-derived platelet units intended for transfusion have improved over the past decades but significant problems still remain. In vitroderived platelets offer a possible alternative but up-scaling production is hindered by our limited understanding of thrombopoie...

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Main Authors: Holly R. Foster, Maria Colzani, Guenaelle Bouet, Daniel Howard, Christian A. Di Buduo, Nicole Müller-Sienerth, Amie K. Waller, Yi Sun, Natalia Davidenko, Jennifer H. Shepherd, Thomas Moreau, Amanda L. Evans, Paolo M. Soprano, Martin E.M. Parsons, Yumi Ying Sims, Meera Arumugam, Wardiya Afshar-Saber, Ernest Turro, Patricia B. Maguire, Serena M. Best, Ruth E. Cameron, Alessandra Balduini, Gavin J. Wright, Cedric Ghevaert
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-04-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12035
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