Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan
Gut microbiota plays a crucial role in human health and can be influenced by environmental factors. While past studies have examined the impact of the environment on gut microbiota, vulnerable populations have often been overlooked. This study aimed to investigate the association between environment...
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Elsevier
2025-02-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001290 |
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| author | Aji Kusumaning Asri Tsunglin Liu Hui-Ju Tsai Jiu-Yao Wang Chih-Da Wu |
| author_facet | Aji Kusumaning Asri Tsunglin Liu Hui-Ju Tsai Jiu-Yao Wang Chih-Da Wu |
| author_sort | Aji Kusumaning Asri |
| collection | DOAJ |
| description | Gut microbiota plays a crucial role in human health and can be influenced by environmental factors. While past studies have examined the impact of the environment on gut microbiota, vulnerable populations have often been overlooked. This study aimed to investigate the association between environmental exposures, air pollution and greenspace, and gut microbiota in asthmatic children. Data were collected during the recovery period for 41 eligible children. Air pollution was estimated using an ensemble learning model that combined regression and machine-learning algorithms, while greenspace was quantified using the normalized difference vegetation index (NDVI) and green land-cover data. The lag effects of exposures were assessed within defined buffer zones surrounding each child's residence. A generalized additive model was applied to examine associations. Results revealed a marginally significant negative association between 1-day lag exposure to NO₂ and gut microbiota indices, such as observed bacteria (Coef.: −1.130; 95 %CI −2.287, 0.027) and bacterial richness (Coef.: −2.420; 95 %CI −4.987, 0.146). The 8-day lagged average exposure to PM2.5 and O₃ also showed negative impacts on bacterial diversity. In contrast, the 1-month lagged average exposure to greenspace was positively associated with microbiota indices. Air pollution and greenspace were also linked to specific bacterial abundances, such as Streptococcus. This study underscores the need for further research on how environmental factors may influence immunity in asthmatic children by altering gut microbiota. |
| format | Article |
| id | doaj-art-d1ca4063f894444bba8ac950248aa2ea |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-d1ca4063f894444bba8ac950248aa2ea2025-02-02T05:26:38ZengElsevierEcotoxicology and Environmental Safety0147-65132025-02-01291117793Environmental exposures related to gut microbiota among children with asthma: a pioneer study in TaiwanAji Kusumaning Asri0Tsunglin Liu1Hui-Ju Tsai2Jiu-Yao Wang3Chih-Da Wu4Department of Geomatics, National Cheng Kung University, Tainan 701, Taiwan, ROCDepartment of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan 701, Taiwan, ROCInstitute of Population Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan, ROCDepartment of Allergy and Immunology, China Medical University Children’s Hospital, Taichung 404, Taiwan, ROC; Allergy, Immunology, and Microbiome (A.I.M.) Research Center, China Medical University, Taichung 404, Taiwan, ROC; Corresponding author at: Department of Allergy and Immunology, China Medical University Children’s Hospital, Taichung 404, Taiwan, ROC.Department of Geomatics, National Cheng Kung University, Tainan 701, Taiwan, ROC; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli 35053, Taiwan, ROC; Innovation and Development Center of Sustainable Agriculture, National Chung Hsing University, Taichung 402, Taiwan, ROC; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Corresponding author at: Department of Geomatics, National Cheng Kung University, Tainan 701, Taiwan, ROC.Gut microbiota plays a crucial role in human health and can be influenced by environmental factors. While past studies have examined the impact of the environment on gut microbiota, vulnerable populations have often been overlooked. This study aimed to investigate the association between environmental exposures, air pollution and greenspace, and gut microbiota in asthmatic children. Data were collected during the recovery period for 41 eligible children. Air pollution was estimated using an ensemble learning model that combined regression and machine-learning algorithms, while greenspace was quantified using the normalized difference vegetation index (NDVI) and green land-cover data. The lag effects of exposures were assessed within defined buffer zones surrounding each child's residence. A generalized additive model was applied to examine associations. Results revealed a marginally significant negative association between 1-day lag exposure to NO₂ and gut microbiota indices, such as observed bacteria (Coef.: −1.130; 95 %CI −2.287, 0.027) and bacterial richness (Coef.: −2.420; 95 %CI −4.987, 0.146). The 8-day lagged average exposure to PM2.5 and O₃ also showed negative impacts on bacterial diversity. In contrast, the 1-month lagged average exposure to greenspace was positively associated with microbiota indices. Air pollution and greenspace were also linked to specific bacterial abundances, such as Streptococcus. This study underscores the need for further research on how environmental factors may influence immunity in asthmatic children by altering gut microbiota.http://www.sciencedirect.com/science/article/pii/S0147651325001290Air pollutionAsthmatic childrenBacterial abundanceGreenspaceGut microbiota |
| spellingShingle | Aji Kusumaning Asri Tsunglin Liu Hui-Ju Tsai Jiu-Yao Wang Chih-Da Wu Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan Ecotoxicology and Environmental Safety Air pollution Asthmatic children Bacterial abundance Greenspace Gut microbiota |
| title | Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan |
| title_full | Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan |
| title_fullStr | Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan |
| title_full_unstemmed | Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan |
| title_short | Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan |
| title_sort | environmental exposures related to gut microbiota among children with asthma a pioneer study in taiwan |
| topic | Air pollution Asthmatic children Bacterial abundance Greenspace Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001290 |
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