Sympathetic reactivity to physiological stress is associated with expanded cardiac extracellular volume in humans

Sympathetic reactivity to physiological stress is associated with expanded cardiac extracellular volume in humans

Abstract Background Expanded extracellular volume (ECV) is an early marker of myocardial interstitial fibrosis in patients with hypertension. Animal studies suggest that surges in sympathetic nerve activity (SNA) might contribute more to the development of interstitial fibrosis than the resting leve...

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Main Authors: Hazel C. Blythe, Zoe H. Adams, Katrina A. Hope, Richard P. Baker, Melanie J. Hezzell, M. Saadeh Suleiman, Ana Paula Abdala Sheikh, Nathan Manghat, Konstantina Mitrousi, Angus K. Nightingale, Emma C. Hart
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Extracellular volume
Cardiac fibrosis
Sympathetic nerve activity
Stressor
Online Access:https://doi.org/10.1186/s12916-025-04197-6
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