Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study
Background. Anemia has up to 87% prevalence in high tuberculosis (TB) and human immunodeficiency virus (HIV) burden settings of the sub-Saharan Africa (SSA) including Ethiopia. It increases lost to follow-up (LTFU) rate, reduces quality of life, and shortens the survival of TB/HIV coinfected patient...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/5555030 |
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| author | Kebede Embaye Gezae Kiflom Hagos Assefa Ayalew Gebreslassie |
| author_facet | Kebede Embaye Gezae Kiflom Hagos Assefa Ayalew Gebreslassie |
| author_sort | Kebede Embaye Gezae |
| collection | DOAJ |
| description | Background. Anemia has up to 87% prevalence in high tuberculosis (TB) and human immunodeficiency virus (HIV) burden settings of the sub-Saharan Africa (SSA) including Ethiopia. It increases lost to follow-up (LTFU) rate, reduces quality of life, and shortens the survival of TB/HIV coinfected patients. However, there is limited information on severity level and determinants of anemia in TB/HIV coinfected adults in the study setting in particular. Therefore, this study is aimed to assess severity level and determinants of TB/HIV-associated anemia. Methods. A hospital based retrospective study was conducted among 305 TB/HIV coinfected adults who enrolled for antiretroviral therapy (ART) from January, 2009 to December, 2016 in two public hospital of Mekelle, Ethiopia, by reviewing ART register. A multiple logit model was fitted to identify the baseline determinants of anemia using 95% confidence level or 5% level of significance for adjusted odds ratio (AOR). Results. In the current study, the cumulative baseline prevalence of anemia was 59.0% (95% CI: 53.3%–64.6%). Considering severity level, the prevalence was 6.2%, 28.2%, and 24.6% for severe, moderate, and mild anemia, respectively. Being female (AOR = 0.380; 95% CI: 0.226–0.640), body mass index (AOR = 0.913; 95% CI: 0.836–0.998) reduces the odds of developing anemia whereas baseline ambulatory functional status (AOR = 2.139; 95% CI: 1.189–3.846), bedridden functional status (AOR = 2.208; 95% CI: 1.002–4.863), HIV clinical stage III (AOR = 2.565; 95% CI: 1.030–6.384), and HIV clinical stage IV (AOR = 2.590; 95% CI: 1.006–6.669) increased the odds of developing anemia for TB/HIV coinfected adults. Conclusions. In the current study, significant TB/HIV-associated severe anemia was assessed which accounted for nearly one-ninth of all anemia cases while nearly half were moderate anemia. Therefore, curious attention has to be given for the management of TB/HIV-associated severe anemia in particular and anemia in general to reducing anemia associated bad outcomes most importantly death. |
| format | Article |
| id | doaj-art-d1bde1da8cde435ba51dd0eb790bfc1b |
| institution | Kabale University |
| issn | 1687-9694 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-d1bde1da8cde435ba51dd0eb790bfc1b2025-02-03T06:42:47ZengWileyJournal of Tropical Medicine1687-96942023-01-01202310.1155/2023/5555030Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective StudyKebede Embaye Gezae0Kiflom Hagos1Assefa Ayalew Gebreslassie2Department of BiostatisticsDepartment of Medical Microbiology and ImmunologyDepartment of Reproductive HealthBackground. Anemia has up to 87% prevalence in high tuberculosis (TB) and human immunodeficiency virus (HIV) burden settings of the sub-Saharan Africa (SSA) including Ethiopia. It increases lost to follow-up (LTFU) rate, reduces quality of life, and shortens the survival of TB/HIV coinfected patients. However, there is limited information on severity level and determinants of anemia in TB/HIV coinfected adults in the study setting in particular. Therefore, this study is aimed to assess severity level and determinants of TB/HIV-associated anemia. Methods. A hospital based retrospective study was conducted among 305 TB/HIV coinfected adults who enrolled for antiretroviral therapy (ART) from January, 2009 to December, 2016 in two public hospital of Mekelle, Ethiopia, by reviewing ART register. A multiple logit model was fitted to identify the baseline determinants of anemia using 95% confidence level or 5% level of significance for adjusted odds ratio (AOR). Results. In the current study, the cumulative baseline prevalence of anemia was 59.0% (95% CI: 53.3%–64.6%). Considering severity level, the prevalence was 6.2%, 28.2%, and 24.6% for severe, moderate, and mild anemia, respectively. Being female (AOR = 0.380; 95% CI: 0.226–0.640), body mass index (AOR = 0.913; 95% CI: 0.836–0.998) reduces the odds of developing anemia whereas baseline ambulatory functional status (AOR = 2.139; 95% CI: 1.189–3.846), bedridden functional status (AOR = 2.208; 95% CI: 1.002–4.863), HIV clinical stage III (AOR = 2.565; 95% CI: 1.030–6.384), and HIV clinical stage IV (AOR = 2.590; 95% CI: 1.006–6.669) increased the odds of developing anemia for TB/HIV coinfected adults. Conclusions. In the current study, significant TB/HIV-associated severe anemia was assessed which accounted for nearly one-ninth of all anemia cases while nearly half were moderate anemia. Therefore, curious attention has to be given for the management of TB/HIV-associated severe anemia in particular and anemia in general to reducing anemia associated bad outcomes most importantly death.http://dx.doi.org/10.1155/2023/5555030 |
| spellingShingle | Kebede Embaye Gezae Kiflom Hagos Assefa Ayalew Gebreslassie Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study Journal of Tropical Medicine |
| title | Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study |
| title_full | Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study |
| title_fullStr | Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study |
| title_full_unstemmed | Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study |
| title_short | Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study |
| title_sort | severity and determinants of anemia in tb hiv coinfected adults at mekelle ethiopia hospital based retrospective study |
| url | http://dx.doi.org/10.1155/2023/5555030 |
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