Nutrigenomic Functions of PPARs in Obesogenic Environments
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments. This review consists of three parts. First, we summarize current...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4794576 |
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| author | Soonkyu Chung Young Jun Kim Soo Jin Yang Yunkyoung Lee Myoungsook Lee |
| author_facet | Soonkyu Chung Young Jun Kim Soo Jin Yang Yunkyoung Lee Myoungsook Lee |
| author_sort | Soonkyu Chung |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments. This review consists of three parts. First, we summarize current knowledge regarding the role of PPARs in governing the development of white and brown/beige adipocytes from uncommitted progenitor cells. Next, we discuss the interactions of dietary bioactive molecules, such as fatty acids and phytochemicals, with PPARs for the modulation of PPAR-dependent transcriptional activities and metabolic consequences. Lastly, the effects of PPAR polymorphism on obesity and metabolic outcomes are discussed. In this review, we aim to highlight the critical role of PPARs in the modulation of adiposity and subsequent metabolic adaptation in response to dietary challenges and genetic modifications. Understanding the changes in obesogenic environments as a consequence of PPARs/nutrient interactions may help expand the field of individualized nutrition to prevent obesity and obesity-associated metabolic comorbidities. |
| format | Article |
| id | doaj-art-d1b2eeda7a76426fbe34ad28ed892105 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-d1b2eeda7a76426fbe34ad28ed8921052025-02-03T06:01:19ZengWileyPPAR Research1687-47571687-47652016-01-01201610.1155/2016/47945764794576Nutrigenomic Functions of PPARs in Obesogenic EnvironmentsSoonkyu Chung0Young Jun Kim1Soo Jin Yang2Yunkyoung Lee3Myoungsook Lee4Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USADepartment of Food & Biotechnology, Korea University, Sejong, Republic of KoreaDepartment of Food and Nutrition, Seoul Women’s University, Seoul, Republic of KoreaDepartment of Food Science and Nutrition, Jeju National University, Jeju, Republic of KoreaDepartment of Food and Nutrition and Research Institute of Obesity Science, Sungshin Women’s University, Seoul, Republic of KoreaPeroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments. This review consists of three parts. First, we summarize current knowledge regarding the role of PPARs in governing the development of white and brown/beige adipocytes from uncommitted progenitor cells. Next, we discuss the interactions of dietary bioactive molecules, such as fatty acids and phytochemicals, with PPARs for the modulation of PPAR-dependent transcriptional activities and metabolic consequences. Lastly, the effects of PPAR polymorphism on obesity and metabolic outcomes are discussed. In this review, we aim to highlight the critical role of PPARs in the modulation of adiposity and subsequent metabolic adaptation in response to dietary challenges and genetic modifications. Understanding the changes in obesogenic environments as a consequence of PPARs/nutrient interactions may help expand the field of individualized nutrition to prevent obesity and obesity-associated metabolic comorbidities.http://dx.doi.org/10.1155/2016/4794576 |
| spellingShingle | Soonkyu Chung Young Jun Kim Soo Jin Yang Yunkyoung Lee Myoungsook Lee Nutrigenomic Functions of PPARs in Obesogenic Environments PPAR Research |
| title | Nutrigenomic Functions of PPARs in Obesogenic Environments |
| title_full | Nutrigenomic Functions of PPARs in Obesogenic Environments |
| title_fullStr | Nutrigenomic Functions of PPARs in Obesogenic Environments |
| title_full_unstemmed | Nutrigenomic Functions of PPARs in Obesogenic Environments |
| title_short | Nutrigenomic Functions of PPARs in Obesogenic Environments |
| title_sort | nutrigenomic functions of ppars in obesogenic environments |
| url | http://dx.doi.org/10.1155/2016/4794576 |
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