Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells

Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells

Ischemic retinopathies, including proliferative diabetic retinopathy (PDR) and retinopathy of prematurity (ROP), are characterized by abnormal retinal neovascularization and can lead to blindness in children and adults. Current treatments, such as intravitreal anti-VEGF injections, face limitations...

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Bibliographic Details
Main Authors: Gabriella D. Hartman, Kamakshi Sishtla, Eyram K. Kpenu, Mahmut Mijit, Anbukkarasi Muniyandi, Ha-Neul Jo, Harald J. Junge, Aaron Shaw, Daniela Bischof, Sheng Liu, Jun Wan, Mark R. Kelley, Timothy W. Corson
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
Wnt signaling
APE1/Ref-1
Retinal neovascularization
Ischemic retinopathy
LRP5
Ref-1 redox activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001594
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