Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review
Breast density (BD) is recognized as one of the strongest independent risk factors of breast cancer (BC). Unlike most other risk factors, BD can be modified, suggesting that it may be a biomarker for preventive interventions. We conducted a qualitative systematic review to address the effect of prev...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/942386 |
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| author | Virginie Lienart Birgit Carly Xin Kang Laura Guzy Anna-Maria Sajovitz Fabienne Liebens |
| author_facet | Virginie Lienart Birgit Carly Xin Kang Laura Guzy Anna-Maria Sajovitz Fabienne Liebens |
| author_sort | Virginie Lienart |
| collection | DOAJ |
| description | Breast density (BD) is recognized as one of the strongest independent risk factors of breast cancer (BC). Unlike most other risk factors, BD can be modified, suggesting that it may be a biomarker for preventive interventions. We conducted a qualitative systematic review to address the effect of preventive hormonal therapy on BD. Among the 26 relevant studies, 10 assessed the effect of tamoxifen on BD (TAM: n=2 877), 9 that of raloxifene (RLX: n=1 544), and 7 that of aromatase inhibitors (AI: n=416). The studies were characterized by a large heterogeneity in designs and in methods of BD measurement. BD could be reduced by TAM (10 studies/10). However, the effect of RLX and AI on BD remains unclear due to conflicting results between studies. Consequently, it is crucial to develop practical, accurate, and reproducible methods of measurement in order to be able to compare the effect of preventive hormonal agents on BD and to determine whether change in BD can be used as a predictor of response to therapy. |
| format | Article |
| id | doaj-art-d18bde3546be4e0fbcd3a519ca4a3d93 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d18bde3546be4e0fbcd3a519ca4a3d932025-02-03T07:25:40ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/942386942386Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative ReviewVirginie Lienart0Birgit Carly1Xin Kang2Laura Guzy3Anna-Maria Sajovitz4Fabienne Liebens5ISALA Breast Unit and Prevention Centre, OB-GYN Department, CHU Saint Pierre, 290 rue Haute, 1000 Brussels, BelgiumISALA Breast Unit and Prevention Centre, OB-GYN Department, CHU Saint Pierre, 290 rue Haute, 1000 Brussels, BelgiumISALA Breast Unit and Prevention Centre, OB-GYN Department, CHU Saint Pierre, 290 rue Haute, 1000 Brussels, BelgiumISALA Breast Unit and Prevention Centre, OB-GYN Department, CHU Saint Pierre, 290 rue Haute, 1000 Brussels, BelgiumISALA Breast Unit and Prevention Centre, OB-GYN Department, CHU Saint Pierre, 290 rue Haute, 1000 Brussels, BelgiumISALA Breast Unit and Prevention Centre, OB-GYN Department, CHU Saint Pierre, 290 rue Haute, 1000 Brussels, BelgiumBreast density (BD) is recognized as one of the strongest independent risk factors of breast cancer (BC). Unlike most other risk factors, BD can be modified, suggesting that it may be a biomarker for preventive interventions. We conducted a qualitative systematic review to address the effect of preventive hormonal therapy on BD. Among the 26 relevant studies, 10 assessed the effect of tamoxifen on BD (TAM: n=2 877), 9 that of raloxifene (RLX: n=1 544), and 7 that of aromatase inhibitors (AI: n=416). The studies were characterized by a large heterogeneity in designs and in methods of BD measurement. BD could be reduced by TAM (10 studies/10). However, the effect of RLX and AI on BD remains unclear due to conflicting results between studies. Consequently, it is crucial to develop practical, accurate, and reproducible methods of measurement in order to be able to compare the effect of preventive hormonal agents on BD and to determine whether change in BD can be used as a predictor of response to therapy.http://dx.doi.org/10.1155/2014/942386 |
| spellingShingle | Virginie Lienart Birgit Carly Xin Kang Laura Guzy Anna-Maria Sajovitz Fabienne Liebens Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review The Scientific World Journal |
| title | Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review |
| title_full | Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review |
| title_fullStr | Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review |
| title_full_unstemmed | Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review |
| title_short | Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review |
| title_sort | effect of preventive hormonal therapy on breast density a systematic qualitative review |
| url | http://dx.doi.org/10.1155/2014/942386 |
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