Use of Cyclosporine in Uterine Transplantation
Uterine transplantation has been proposed as a possible solution to absolute uterine factor infertility untreatable by any other option. Since the first human attempt in 2000, various teams have tried to clarify which immunosuppressant would be most suitable for protecting the allogeneic uterine gra...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/134936 |
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| author | Srdjan Saso Karl Logan Yazan Abdallah Louay S. Louis Sadaf Ghaem-Maghami J. Richard Smith Giuseppe Del Priore |
| author_facet | Srdjan Saso Karl Logan Yazan Abdallah Louay S. Louis Sadaf Ghaem-Maghami J. Richard Smith Giuseppe Del Priore |
| author_sort | Srdjan Saso |
| collection | DOAJ |
| description | Uterine transplantation has been proposed as a possible solution to absolute uterine factor infertility untreatable by any other option. Since the first human attempt in 2000, various teams have tried to clarify which immunosuppressant would be most suitable for protecting the allogeneic uterine graft while posing a minimal risk to the fetus. Cyclosporine A (CsA) is an immunosuppressant widely used by transplant recipients. It is currently being tested as a potential immunosuppressant to be used during UTn. Its effect on the mother and fetus and its influence upon the graft during pregnancy have been of major concern. We review the role of CsA in UTn and its effect on pregnant transplant recipients and their offspring. |
| format | Article |
| id | doaj-art-d183110ee4434ad1b395a0da0e1c9e48 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-d183110ee4434ad1b395a0da0e1c9e482025-02-03T01:12:15ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/134936134936Use of Cyclosporine in Uterine TransplantationSrdjan Saso0Karl Logan1Yazan Abdallah2Louay S. Louis3Sadaf Ghaem-Maghami4J. Richard Smith5Giuseppe Del Priore6Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UKDivision of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UKDivision of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UKDivision of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UKGynaecological Oncology, West London Gynaecological Cancer Centre, Queen Charlotte's Hospital, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UKGynaecological Oncology, West London Gynaecological Cancer Centre, Queen Charlotte's Hospital, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UKMelvin and Bren Simon Cancer Center, Indianapolis, Indiana University School of Medicine, Simon Cancer Center, Indianapolis, IN 46202, USAUterine transplantation has been proposed as a possible solution to absolute uterine factor infertility untreatable by any other option. Since the first human attempt in 2000, various teams have tried to clarify which immunosuppressant would be most suitable for protecting the allogeneic uterine graft while posing a minimal risk to the fetus. Cyclosporine A (CsA) is an immunosuppressant widely used by transplant recipients. It is currently being tested as a potential immunosuppressant to be used during UTn. Its effect on the mother and fetus and its influence upon the graft during pregnancy have been of major concern. We review the role of CsA in UTn and its effect on pregnant transplant recipients and their offspring.http://dx.doi.org/10.1155/2012/134936 |
| spellingShingle | Srdjan Saso Karl Logan Yazan Abdallah Louay S. Louis Sadaf Ghaem-Maghami J. Richard Smith Giuseppe Del Priore Use of Cyclosporine in Uterine Transplantation Journal of Transplantation |
| title | Use of Cyclosporine in Uterine Transplantation |
| title_full | Use of Cyclosporine in Uterine Transplantation |
| title_fullStr | Use of Cyclosporine in Uterine Transplantation |
| title_full_unstemmed | Use of Cyclosporine in Uterine Transplantation |
| title_short | Use of Cyclosporine in Uterine Transplantation |
| title_sort | use of cyclosporine in uterine transplantation |
| url | http://dx.doi.org/10.1155/2012/134936 |
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