Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review
Background: Excess fructose consumption has been linked to adverse metabolic health, including impaired hepatic function and increased adiposity. The early life period, including preconception, pregnancy, and the newborn period, are critical periods in determining later metabolic health. However, th...
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Elsevier
2025-01-01
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| Series: | Current Developments in Nutrition |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2475299124024442 |
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| author | Grace Zhao Sarah Chondon Clint Gray Sheridan Gentili Meagan Stanley Timothy RH Regnault |
| author_facet | Grace Zhao Sarah Chondon Clint Gray Sheridan Gentili Meagan Stanley Timothy RH Regnault |
| author_sort | Grace Zhao |
| collection | DOAJ |
| description | Background: Excess fructose consumption has been linked to adverse metabolic health, including impaired hepatic function and increased adiposity. The early life period, including preconception, pregnancy, and the newborn period, are critical periods in determining later metabolic health. However, the impact of excess fructose intake during this time on maternal, fetal, and offspring hepatic and whole-body adiposity, is not well defined. Objectives: To understand the effects of maternal fructose consumption pre- and during pregnancy on maternal, fetal, and offspring hepatic and whole-body adiposity. Methods: A systematic search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed up to October 4, 2024, to identify animal and human studies that focused on maternal fructose consumption pre- and during pregnancy on hepatic and whole-body adiposity in the mother, fetus, and offspring. Citations, abstracts, and full texts were screened in duplicate. Hepatic adiposity was defined as elevated hepatic triglycerides or overall hepatic lipid accumulation. Whole-body adiposity was defined as increased adipose tissue, serum lipids, or adipocyte hypertrophy. Results: After screening 2538 citations, 37 experimental rodent studies reporting maternal fructose consumption pre- and during pregnancy in rodents were included. No human studies met the inclusion criteria. Prenatal fructose exposure was associated with maternal (9 of 12) and offspring (7 of 11) whole-body adiposity. A high proportion of studies (13 of 14) supported the association between fructose during pregnancy and increased maternal hepatic adiposity. Fetal hepatic adiposity and elevated expression of hepatic lipogenic proteins were noted in 4 studies. Offspring hepatic adiposity was supported in 16 of the 20 articles that discussed hepatic results, with 5 studies demonstrating more severe effects in female offspring. Conclusions: Fructose consumption during pregnancy in rodent models is associated with maternal, fetal, and offspring hepatic and whole-body adiposity with underlying sex-specific effects. No human studies met the inclusion criteria. Registration number: H8F26 on Open Science Framework (https://doi.org/10.17605/OSF.IO/H8F26) |
| format | Article |
| id | doaj-art-d18099695aa2482c8cfae61b94a69e83 |
| institution | Kabale University |
| issn | 2475-2991 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Developments in Nutrition |
| spelling | doaj-art-d18099695aa2482c8cfae61b94a69e832025-01-23T05:27:29ZengElsevierCurrent Developments in Nutrition2475-29912025-01-0191104510Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping ReviewGrace Zhao0Sarah Chondon1Clint Gray2Sheridan Gentili3Meagan Stanley4Timothy RH Regnault5Department of Obstetrics and Gynaecology, Western University, London, ON, Canada; Corresponding author.Department of Obstetrics and Gynaecology, Schulich School of Medicine, Western University, London, ON, CanadaGillies McIndoe Research Institute, New Zealand; Department of Paediatrics & Child Health, University of Otago, New ZealandTeaching Innovation Unit, University of South Australia, AustraliaWestern Libraries, Western University, London, ON, CanadaDepartment of Obstetrics and Gynaecology, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Western University, London, ON, Canada; Division of Maternal, Fetal, and Newborn Health, Children’s Health Research Institute, London, ON, CanadaBackground: Excess fructose consumption has been linked to adverse metabolic health, including impaired hepatic function and increased adiposity. The early life period, including preconception, pregnancy, and the newborn period, are critical periods in determining later metabolic health. However, the impact of excess fructose intake during this time on maternal, fetal, and offspring hepatic and whole-body adiposity, is not well defined. Objectives: To understand the effects of maternal fructose consumption pre- and during pregnancy on maternal, fetal, and offspring hepatic and whole-body adiposity. Methods: A systematic search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed up to October 4, 2024, to identify animal and human studies that focused on maternal fructose consumption pre- and during pregnancy on hepatic and whole-body adiposity in the mother, fetus, and offspring. Citations, abstracts, and full texts were screened in duplicate. Hepatic adiposity was defined as elevated hepatic triglycerides or overall hepatic lipid accumulation. Whole-body adiposity was defined as increased adipose tissue, serum lipids, or adipocyte hypertrophy. Results: After screening 2538 citations, 37 experimental rodent studies reporting maternal fructose consumption pre- and during pregnancy in rodents were included. No human studies met the inclusion criteria. Prenatal fructose exposure was associated with maternal (9 of 12) and offspring (7 of 11) whole-body adiposity. A high proportion of studies (13 of 14) supported the association between fructose during pregnancy and increased maternal hepatic adiposity. Fetal hepatic adiposity and elevated expression of hepatic lipogenic proteins were noted in 4 studies. Offspring hepatic adiposity was supported in 16 of the 20 articles that discussed hepatic results, with 5 studies demonstrating more severe effects in female offspring. Conclusions: Fructose consumption during pregnancy in rodent models is associated with maternal, fetal, and offspring hepatic and whole-body adiposity with underlying sex-specific effects. No human studies met the inclusion criteria. Registration number: H8F26 on Open Science Framework (https://doi.org/10.17605/OSF.IO/H8F26)http://www.sciencedirect.com/science/article/pii/S2475299124024442fructosepreconceptionpregnancyoffspringhepatic adipositywhole-body adiposity |
| spellingShingle | Grace Zhao Sarah Chondon Clint Gray Sheridan Gentili Meagan Stanley Timothy RH Regnault Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review Current Developments in Nutrition fructose preconception pregnancy offspring hepatic adiposity whole-body adiposity |
| title | Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review |
| title_full | Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review |
| title_fullStr | Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review |
| title_full_unstemmed | Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review |
| title_short | Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review |
| title_sort | fructose consumption in pregnancy and associations with maternal and offspring hepatic and whole body adiposity in rodents a scoping review |
| topic | fructose preconception pregnancy offspring hepatic adiposity whole-body adiposity |
| url | http://www.sciencedirect.com/science/article/pii/S2475299124024442 |
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