Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole

Nine new S-β-D-glucosides containing 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols have been synthesized by the direct glycosylation of 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide in ethanol in the presence of potassium hyd...

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Main Authors: Shujun Chao, Yingling Wang
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/568907
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author Shujun Chao
Yingling Wang
author_facet Shujun Chao
Yingling Wang
author_sort Shujun Chao
collection DOAJ
description Nine new S-β-D-glucosides containing 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols have been synthesized by the direct glycosylation of 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide in ethanol in the presence of potassium hydroxide followed by deacetylation using dry ammonia in dry methanol. All the compounds synthesized have been characterized by their elemental analyses and spectral data.
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institution Kabale University
issn 2090-9063
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spelling doaj-art-d17c969845634ac9bf6e1b9dea2dc7892025-02-03T01:28:37ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/568907568907Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-TriazoleShujun Chao0Yingling Wang1Department of Chemistry, Xinxiang Medical University, Henan, Xinxiang 453003, ChinaDepartment of Chemistry, Xinxiang Medical University, Henan, Xinxiang 453003, ChinaNine new S-β-D-glucosides containing 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols have been synthesized by the direct glycosylation of 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide in ethanol in the presence of potassium hydroxide followed by deacetylation using dry ammonia in dry methanol. All the compounds synthesized have been characterized by their elemental analyses and spectral data.http://dx.doi.org/10.1155/2013/568907
spellingShingle Shujun Chao
Yingling Wang
Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole
Journal of Chemistry
title Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole
title_full Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole
title_fullStr Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole
title_full_unstemmed Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole
title_short Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole
title_sort synthesis of novel s glucosides containing 5 methylisoxazole substituted 1 2 4 triazole
url http://dx.doi.org/10.1155/2013/568907
work_keys_str_mv AT shujunchao synthesisofnovelsglucosidescontaining5methylisoxazolesubstituted124triazole
AT yinglingwang synthesisofnovelsglucosidescontaining5methylisoxazolesubstituted124triazole