The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus
The increase in cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is not fully explained by traditional CVD risk factors. Regulatory T cells (Treg cells) are considered atheroprotective. We investigated the relationship between the absolute number of different phenotyp...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/3271572 |
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| author | Mario García-Carrasco Pamela Soto-Santillán Claudia Mendoza-Pinto Rebeca González-Ramírez Ana Lidia López-Carmona Pamela Munguía-Realpozo Ivet Etchegaray-Morales Socorro Méndez-Martínez José Luis Gálvez-Romero Aurelio López-Colombo Alejandro Ruiz-Arguelles |
| author_facet | Mario García-Carrasco Pamela Soto-Santillán Claudia Mendoza-Pinto Rebeca González-Ramírez Ana Lidia López-Carmona Pamela Munguía-Realpozo Ivet Etchegaray-Morales Socorro Méndez-Martínez José Luis Gálvez-Romero Aurelio López-Colombo Alejandro Ruiz-Arguelles |
| author_sort | Mario García-Carrasco |
| collection | DOAJ |
| description | The increase in cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is not fully explained by traditional CVD risk factors. Regulatory T cells (Treg cells) are considered atheroprotective. We investigated the relationship between the absolute number of different phenotypes of Treg cells and abnormal carotid intima-media thickness (IMT) in women with SLE. Sixty-six women with SLE with no history of CV disease were included. Carotid IMT was quantified by ultrasound. Abnormal carotid IMT was defined as ≥0.8 mm and two groups were compared according to this definition. Flow cytometry was used to analyze Foxp3 and Helios expression in peripheral blood CD4 T cells. A significantly higher level of absolute CD4+CD25+FoxP3high T cells was present in patients with abnormal carotid IMT compared with those without (1.795±4.182 cells/μl vs. 0.274±0.784 cells/μl; p=0.003). However, no correlations were found between any Treg cell phenotypes and carotid IMT. Only the absolute number of CD4+CD45RA+FoxP3low T cells was significantly decreased in SLE patients with low HDL cholesterol compared with those with normal HDL cholesterol (0.609±2.362 cells/μl vs. 1.802±4.647 cells/μl; p=0.009 and 15.358±11.608 cells/μl vs. 28.274±34.139; p=0.012, respectively). In conclusion, in SLE women, diminished levels of Treg cells based on flow cytometry were not a good indicator of abnormal carotid IMT. |
| format | Article |
| id | doaj-art-d178569d39e847c7bd3da71683074599 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d178569d39e847c7bd3da716830745992025-02-03T01:00:01ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/32715723271572The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus ErythematosusMario García-Carrasco0Pamela Soto-Santillán1Claudia Mendoza-Pinto2Rebeca González-Ramírez3Ana Lidia López-Carmona4Pamela Munguía-Realpozo5Ivet Etchegaray-Morales6Socorro Méndez-Martínez7José Luis Gálvez-Romero8Aurelio López-Colombo9Alejandro Ruiz-Arguelles10Systemic Autoimmune Diseases Research Unit, Medical Unit of High Specialty, Manuel Ávila Camacho National Medical Center-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, MexicoSystemic Autoimmune Diseases Research Unit, Medical Unit of High Specialty, Manuel Ávila Camacho National Medical Center-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, MexicoSystemic Autoimmune Diseases Research Unit, Medical Unit of High Specialty, Manuel Ávila Camacho National Medical Center-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, MexicoMedical Sciences and Research, Medicine School, Benemérita Universidad Autónoma de Puebla, MexicoLaboratorios Clínicos de Puebla, Puebla, MexicoSystemic Autoimmune Diseases Research Unit, Medical Unit of High Specialty, Manuel Ávila Camacho National Medical Center-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, MexicoImmunology and Rheumatology, Medicine School, Benemérita Universidad Autónoma de Puebla, MexicoCoordination in Health Research, Puebla Delegation, Instituto Mexicano del Seguro Social, Puebla, MexicoImmunology Department, Instituto del Seguro Social al Servicio de los Trabajadores del Estado, Puebla, MexicoCoordination in Health Research, Puebla Delegation, Instituto Mexicano del Seguro Social, Puebla, MexicoLaboratorios Clínicos de Puebla, Puebla, MexicoThe increase in cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is not fully explained by traditional CVD risk factors. Regulatory T cells (Treg cells) are considered atheroprotective. We investigated the relationship between the absolute number of different phenotypes of Treg cells and abnormal carotid intima-media thickness (IMT) in women with SLE. Sixty-six women with SLE with no history of CV disease were included. Carotid IMT was quantified by ultrasound. Abnormal carotid IMT was defined as ≥0.8 mm and two groups were compared according to this definition. Flow cytometry was used to analyze Foxp3 and Helios expression in peripheral blood CD4 T cells. A significantly higher level of absolute CD4+CD25+FoxP3high T cells was present in patients with abnormal carotid IMT compared with those without (1.795±4.182 cells/μl vs. 0.274±0.784 cells/μl; p=0.003). However, no correlations were found between any Treg cell phenotypes and carotid IMT. Only the absolute number of CD4+CD45RA+FoxP3low T cells was significantly decreased in SLE patients with low HDL cholesterol compared with those with normal HDL cholesterol (0.609±2.362 cells/μl vs. 1.802±4.647 cells/μl; p=0.009 and 15.358±11.608 cells/μl vs. 28.274±34.139; p=0.012, respectively). In conclusion, in SLE women, diminished levels of Treg cells based on flow cytometry were not a good indicator of abnormal carotid IMT.http://dx.doi.org/10.1155/2018/3271572 |
| spellingShingle | Mario García-Carrasco Pamela Soto-Santillán Claudia Mendoza-Pinto Rebeca González-Ramírez Ana Lidia López-Carmona Pamela Munguía-Realpozo Ivet Etchegaray-Morales Socorro Méndez-Martínez José Luis Gálvez-Romero Aurelio López-Colombo Alejandro Ruiz-Arguelles The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus Mediators of Inflammation |
| title | The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus |
| title_full | The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus |
| title_fullStr | The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus |
| title_full_unstemmed | The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus |
| title_short | The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus |
| title_sort | role of circulating regulatory t cell levels on subclinical atherosclerosis and cardiovascular risk factors in women with systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2018/3271572 |
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