Association between Anemia and Risk of Parkinson Disease
Background and Objective. People with anemia have higher rates of developing Parkinson disease (PD) than the general population. Previous epidemiological studies have invested the risk of PD in patients with anemia. However, the findings are still inconclusive. Therefore, we did a systematic review...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/8360627 |
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| author | Yao-Chin Wang Abel Po-Hao Huang Sheng-Po Yuan Chu-Ya Huang Chieh-Chen Wu Tahmina Nasrin Poly Suleman Atique Woon-Man Kung |
| author_facet | Yao-Chin Wang Abel Po-Hao Huang Sheng-Po Yuan Chu-Ya Huang Chieh-Chen Wu Tahmina Nasrin Poly Suleman Atique Woon-Man Kung |
| author_sort | Yao-Chin Wang |
| collection | DOAJ |
| description | Background and Objective. People with anemia have higher rates of developing Parkinson disease (PD) than the general population. Previous epidemiological studies have invested the risk of PD in patients with anemia. However, the findings are still inconclusive. Therefore, we did a systematic review with meta-analysis to clarify the association between anemia and risk of PD. Methods. We systematically searched articles on electronic databases such as PubMed, Embase, Scopus, and Google Scholar between January 1, 2000 and July 30, 2020. Articles were independently evaluated by two authors. We included observational studies (case-control and cohort) and calculated the risk ratios (RRs) for associated with anemia and PD. Heterogeneity among the studies was assessed using the Q and I2 statistic. We utilized the random-effect model to calculate the overall RR with 95% CI. Results. A total of 342 articles were identified in the initial searches, and 7 full-text articles were evaluated for eligibility. Three articles were further excluded for prespecified reasons including insufficient data and duplications, and 4 articles were included in our systematic review and meta-analysis. A random effect model meta-analysis of all 4 studies showed no increased risk of PD in patients with anemia (N=4, RRadjusted=1.17 (95% CI: 0.94-1.45, p=0.15). However, heterogeneity among the studies was significant (I2=92.60, p=<0.0001). The pooled relative risk of PD in female patients with anemia was higher (N=3, RRadjusted=1.14 (95% CI: 0.83-1.57, p=0.40) as compared to male patients with anemia (N=3, RRadjusted=1.09 (95% CI: 0.83-1.42, p=0.51). Conclusion. This is the first meta-analysis that shows that anemia is associated with higher risk of PD when compared with patients without anemia. However, more studies are warranted to evaluate the risk of PD among patients with anemia. |
| format | Article |
| id | doaj-art-d16875f35fa6468fbd626828258a6adf |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-d16875f35fa6468fbd626828258a6adf2025-02-03T01:27:00ZengWileyBehavioural Neurology0953-41801875-85842021-01-01202110.1155/2021/83606278360627Association between Anemia and Risk of Parkinson DiseaseYao-Chin Wang0Abel Po-Hao Huang1Sheng-Po Yuan2Chu-Ya Huang3Chieh-Chen Wu4Tahmina Nasrin Poly5Suleman Atique6Woon-Man Kung7Department of Emergency, Min-Sheng General Hospital, Taoyuan, TaiwanDivision of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanTaiwan College of Healthcare Executives, Taipei, TaiwanDepartment of Exercise and Health Promotion, College of Kinesiology and Health, Chinese Culture University, Taipei, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanDepartment of Health Informatics, College of Public Health and Health Informatics, University of Ha’il, Ha’il, Saudi ArabiaDepartment of Exercise and Health Promotion, College of Kinesiology and Health, Chinese Culture University, Taipei, TaiwanBackground and Objective. People with anemia have higher rates of developing Parkinson disease (PD) than the general population. Previous epidemiological studies have invested the risk of PD in patients with anemia. However, the findings are still inconclusive. Therefore, we did a systematic review with meta-analysis to clarify the association between anemia and risk of PD. Methods. We systematically searched articles on electronic databases such as PubMed, Embase, Scopus, and Google Scholar between January 1, 2000 and July 30, 2020. Articles were independently evaluated by two authors. We included observational studies (case-control and cohort) and calculated the risk ratios (RRs) for associated with anemia and PD. Heterogeneity among the studies was assessed using the Q and I2 statistic. We utilized the random-effect model to calculate the overall RR with 95% CI. Results. A total of 342 articles were identified in the initial searches, and 7 full-text articles were evaluated for eligibility. Three articles were further excluded for prespecified reasons including insufficient data and duplications, and 4 articles were included in our systematic review and meta-analysis. A random effect model meta-analysis of all 4 studies showed no increased risk of PD in patients with anemia (N=4, RRadjusted=1.17 (95% CI: 0.94-1.45, p=0.15). However, heterogeneity among the studies was significant (I2=92.60, p=<0.0001). The pooled relative risk of PD in female patients with anemia was higher (N=3, RRadjusted=1.14 (95% CI: 0.83-1.57, p=0.40) as compared to male patients with anemia (N=3, RRadjusted=1.09 (95% CI: 0.83-1.42, p=0.51). Conclusion. This is the first meta-analysis that shows that anemia is associated with higher risk of PD when compared with patients without anemia. However, more studies are warranted to evaluate the risk of PD among patients with anemia.http://dx.doi.org/10.1155/2021/8360627 |
| spellingShingle | Yao-Chin Wang Abel Po-Hao Huang Sheng-Po Yuan Chu-Ya Huang Chieh-Chen Wu Tahmina Nasrin Poly Suleman Atique Woon-Man Kung Association between Anemia and Risk of Parkinson Disease Behavioural Neurology |
| title | Association between Anemia and Risk of Parkinson Disease |
| title_full | Association between Anemia and Risk of Parkinson Disease |
| title_fullStr | Association between Anemia and Risk of Parkinson Disease |
| title_full_unstemmed | Association between Anemia and Risk of Parkinson Disease |
| title_short | Association between Anemia and Risk of Parkinson Disease |
| title_sort | association between anemia and risk of parkinson disease |
| url | http://dx.doi.org/10.1155/2021/8360627 |
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