Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy
A single nanoparticle (NP) capable of simultaneously performing multiple bioimaging and therapeutic functions is an innovative approach to advance the field of cancer diagnostics and treatment. Here we report a facile synthesis approach to produce magnetic-plasmonic core-shell nanostars. These NPs c...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Materials Today Advances |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590049824000924 |
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| author | Jiamin Xu Koen Evers Yu-chien Lin Taveer A. Tabish Qiyu Zhang Ren-Jei Chung Mary P. Ryan Fang Xie |
| author_facet | Jiamin Xu Koen Evers Yu-chien Lin Taveer A. Tabish Qiyu Zhang Ren-Jei Chung Mary P. Ryan Fang Xie |
| author_sort | Jiamin Xu |
| collection | DOAJ |
| description | A single nanoparticle (NP) capable of simultaneously performing multiple bioimaging and therapeutic functions is an innovative approach to advance the field of cancer diagnostics and treatment. Here we report a facile synthesis approach to produce magnetic-plasmonic core-shell nanostars. These NPs consist of an Fe3O4 core, silica intermediate shell, and outer spiky gold nanostar shell. Remarkably, these core-shell NPs exhibit outstanding magnetisation and tuneable localized surface plasmon resonance (LSPR) spanning from visible to Near Infrared (NIR) wavelengths. Through incorporation of Indocyanine Green (ICG) and subsequent coating with bovine serum albumin (BSA), the obtained NPs demonstrate dual imaging capabilities in the form of magnetic resonance imaging (MRI) which offers high spatial resolution and deep tissue penetration and Surface-Enhanced Raman Scattering (SERS) which can provide the ultrasensitive molecular detection which MRI lacks. More significantly, they also exhibit significant potential to be used in photothermal therapy (PTT). These multi-functional NPs show minimal cytotoxicity when exposed to cells even at high concentrations, positioning them as promising candidates for future in vivo studies centred around imaging-guided photothermal therapy. |
| format | Article |
| id | doaj-art-d15e4aa9f5d34f77b23a42b59c1a47e6 |
| institution | DOAJ |
| issn | 2590-0498 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Advances |
| spelling | doaj-art-d15e4aa9f5d34f77b23a42b59c1a47e62025-08-20T02:57:33ZengElsevierMaterials Today Advances2590-04982025-03-012510055510.1016/j.mtadv.2024.100555Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapyJiamin Xu0Koen Evers1Yu-chien Lin2Taveer A. Tabish3Qiyu Zhang4Ren-Jei Chung5Mary P. Ryan6Fang Xie7Department of Material, Royal School of Mine, Imperial College London, South Kensington Campus, SW7 2AZ, London, UKDepartment of Material, Royal School of Mine, Imperial College London, South Kensington Campus, SW7 2AZ, London, UKDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, 10608, Taiwan, Republic of ChinaRadcliffe Department of Medicine, University of Oxford, Headington, OX37BN, Oxford, UKDepartment of Material, Royal School of Mine, Imperial College London, South Kensington Campus, SW7 2AZ, London, UKDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, 10608, Taiwan, Republic of ChinaDepartment of Material, Royal School of Mine, Imperial College London, South Kensington Campus, SW7 2AZ, London, UK; Corresponding author.Department of Material, Royal School of Mine, Imperial College London, South Kensington Campus, SW7 2AZ, London, UK; Corresponding author.A single nanoparticle (NP) capable of simultaneously performing multiple bioimaging and therapeutic functions is an innovative approach to advance the field of cancer diagnostics and treatment. Here we report a facile synthesis approach to produce magnetic-plasmonic core-shell nanostars. These NPs consist of an Fe3O4 core, silica intermediate shell, and outer spiky gold nanostar shell. Remarkably, these core-shell NPs exhibit outstanding magnetisation and tuneable localized surface plasmon resonance (LSPR) spanning from visible to Near Infrared (NIR) wavelengths. Through incorporation of Indocyanine Green (ICG) and subsequent coating with bovine serum albumin (BSA), the obtained NPs demonstrate dual imaging capabilities in the form of magnetic resonance imaging (MRI) which offers high spatial resolution and deep tissue penetration and Surface-Enhanced Raman Scattering (SERS) which can provide the ultrasensitive molecular detection which MRI lacks. More significantly, they also exhibit significant potential to be used in photothermal therapy (PTT). These multi-functional NPs show minimal cytotoxicity when exposed to cells even at high concentrations, positioning them as promising candidates for future in vivo studies centred around imaging-guided photothermal therapy.http://www.sciencedirect.com/science/article/pii/S2590049824000924 |
| spellingShingle | Jiamin Xu Koen Evers Yu-chien Lin Taveer A. Tabish Qiyu Zhang Ren-Jei Chung Mary P. Ryan Fang Xie Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy Materials Today Advances |
| title | Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy |
| title_full | Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy |
| title_fullStr | Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy |
| title_full_unstemmed | Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy |
| title_short | Near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy |
| title_sort | near infrared window active magnetic core spiky gold nanostars for dual mode imaging and photothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590049824000924 |
| work_keys_str_mv | AT jiaminxu nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy AT koenevers nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy AT yuchienlin nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy AT taveeratabish nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy AT qiyuzhang nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy AT renjeichung nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy AT marypryan nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy AT fangxie nearinfraredwindowactivemagneticcorespikygoldnanostarsfordualmodeimagingandphotothermaltherapy |