Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection
H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated disea...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/4927964 |
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| author | Rong Li Xiao-xia Jiang Lin-fang Zhang Xiao-ming Liu Ting-zi Hu Xiu-juan Xia Ming Li Can-xia Xu |
| author_facet | Rong Li Xiao-xia Jiang Lin-fang Zhang Xiao-ming Liu Ting-zi Hu Xiu-juan Xia Ming Li Can-xia Xu |
| author_sort | Rong Li |
| collection | DOAJ |
| description | H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are promoted by the formation of immunosuppressive microenvironment. But whether group 2 innate lymphoid cells (ILC2s) plays a critical role in H. pylori-induced skewed type 2 immunity is still unclear. In the present study, firstly, we confirmed that type 1 immunity was inhibited and type 2 immunity were undisturbed or promoted after H. pylori infection in vitro and in vivo. Secondly, GATA-3 was firstly found to be increased in the interstitial lymphocytes from H. pylori-associated gastric cancer, among them, Lin−GATA-3+ cells and Lin+GATA-3+ cells were also found to be enhanced, which indicated an important role for ILC2s in H. pylori infection. More importantly, ILC2s were found to be increased after H. pylori infection in clinical patients and animal models. In conclusion, our results indicated that ILC2-mediated innate immune response might play a potential role in dominant type 2 phenotype and immunosuppressive microenvironment in H. pylori infection. |
| format | Article |
| id | doaj-art-d15d12ca2be44e6d8e4ad01b62ace5e7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d15d12ca2be44e6d8e4ad01b62ace5e72025-02-03T01:24:24ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/49279644927964Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori InfectionRong Li0Xiao-xia Jiang1Lin-fang Zhang2Xiao-ming Liu3Ting-zi Hu4Xiu-juan Xia5Ming Li6Can-xia Xu7Department of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, ChinaH. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are promoted by the formation of immunosuppressive microenvironment. But whether group 2 innate lymphoid cells (ILC2s) plays a critical role in H. pylori-induced skewed type 2 immunity is still unclear. In the present study, firstly, we confirmed that type 1 immunity was inhibited and type 2 immunity were undisturbed or promoted after H. pylori infection in vitro and in vivo. Secondly, GATA-3 was firstly found to be increased in the interstitial lymphocytes from H. pylori-associated gastric cancer, among them, Lin−GATA-3+ cells and Lin+GATA-3+ cells were also found to be enhanced, which indicated an important role for ILC2s in H. pylori infection. More importantly, ILC2s were found to be increased after H. pylori infection in clinical patients and animal models. In conclusion, our results indicated that ILC2-mediated innate immune response might play a potential role in dominant type 2 phenotype and immunosuppressive microenvironment in H. pylori infection.http://dx.doi.org/10.1155/2017/4927964 |
| spellingShingle | Rong Li Xiao-xia Jiang Lin-fang Zhang Xiao-ming Liu Ting-zi Hu Xiu-juan Xia Ming Li Can-xia Xu Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection Mediators of Inflammation |
| title | Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection |
| title_full | Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection |
| title_fullStr | Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection |
| title_full_unstemmed | Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection |
| title_short | Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection |
| title_sort | group 2 innate lymphoid cells are involved in skewed type 2 immunity of gastric diseases induced by helicobacter pylori infection |
| url | http://dx.doi.org/10.1155/2017/4927964 |
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