Oral submucous fibrosis: pathogenesis and therapeutic approaches
Abstract Oral submucous fibrosis (OSF), characterized by excessive deposition of extracellular matrix (ECM) that causes oral mucosal tissue sclerosis, and even cancer transformation, is a chronic, progressive fibrosis disease. However, despite some advancements in recent years, no targeted antifibro...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-02-01
|
| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-024-00344-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571958959538176 |
|---|---|
| author | Jianfei Tang Junjie Liu Zekun Zhou Xinyan Cui Hua Tu Jia Jia Baike Chen Xiaohan Dai Ousheng Liu |
| author_facet | Jianfei Tang Junjie Liu Zekun Zhou Xinyan Cui Hua Tu Jia Jia Baike Chen Xiaohan Dai Ousheng Liu |
| author_sort | Jianfei Tang |
| collection | DOAJ |
| description | Abstract Oral submucous fibrosis (OSF), characterized by excessive deposition of extracellular matrix (ECM) that causes oral mucosal tissue sclerosis, and even cancer transformation, is a chronic, progressive fibrosis disease. However, despite some advancements in recent years, no targeted antifibrotic strategies for OSF have been approved; likely because the complicated mechanisms that initiate and drive fibrosis remain to be determined. In this review, we briefly introduce the epidemiology and etiology of OSF. Then, we highlight how cell-intrinsic changes in significant structural cells can drive fibrotic response by regulating biological behaviors, secretion function, and activation of ECM-producing myofibroblasts. In addition, we also discuss the role of innate and adaptive immune cells and how they contribute to the pathogenesis of OSF. Finally, we summarize strategies to interrupt key mechanisms that cause OSF, including modulation of the ECM, inhibition of inflammation, improvement of vascular disturbance. This review will provide potential routes for developing novel anti-OSF therapeutics. |
| format | Article |
| id | doaj-art-d15b6fe7d30a43bc82cdecd7644d6088 |
| institution | Kabale University |
| issn | 2049-3169 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj-art-d15b6fe7d30a43bc82cdecd7644d60882025-02-02T12:11:30ZengNature Publishing GroupInternational Journal of Oral Science2049-31692025-02-0117111510.1038/s41368-024-00344-6Oral submucous fibrosis: pathogenesis and therapeutic approachesJianfei Tang0Junjie Liu1Zekun Zhou2Xinyan Cui3Hua Tu4Jia Jia5Baike Chen6Xiaohan Dai7Ousheng Liu8Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-Maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South UniversityAbstract Oral submucous fibrosis (OSF), characterized by excessive deposition of extracellular matrix (ECM) that causes oral mucosal tissue sclerosis, and even cancer transformation, is a chronic, progressive fibrosis disease. However, despite some advancements in recent years, no targeted antifibrotic strategies for OSF have been approved; likely because the complicated mechanisms that initiate and drive fibrosis remain to be determined. In this review, we briefly introduce the epidemiology and etiology of OSF. Then, we highlight how cell-intrinsic changes in significant structural cells can drive fibrotic response by regulating biological behaviors, secretion function, and activation of ECM-producing myofibroblasts. In addition, we also discuss the role of innate and adaptive immune cells and how they contribute to the pathogenesis of OSF. Finally, we summarize strategies to interrupt key mechanisms that cause OSF, including modulation of the ECM, inhibition of inflammation, improvement of vascular disturbance. This review will provide potential routes for developing novel anti-OSF therapeutics.https://doi.org/10.1038/s41368-024-00344-6 |
| spellingShingle | Jianfei Tang Junjie Liu Zekun Zhou Xinyan Cui Hua Tu Jia Jia Baike Chen Xiaohan Dai Ousheng Liu Oral submucous fibrosis: pathogenesis and therapeutic approaches International Journal of Oral Science |
| title | Oral submucous fibrosis: pathogenesis and therapeutic approaches |
| title_full | Oral submucous fibrosis: pathogenesis and therapeutic approaches |
| title_fullStr | Oral submucous fibrosis: pathogenesis and therapeutic approaches |
| title_full_unstemmed | Oral submucous fibrosis: pathogenesis and therapeutic approaches |
| title_short | Oral submucous fibrosis: pathogenesis and therapeutic approaches |
| title_sort | oral submucous fibrosis pathogenesis and therapeutic approaches |
| url | https://doi.org/10.1038/s41368-024-00344-6 |
| work_keys_str_mv | AT jianfeitang oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT junjieliu oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT zekunzhou oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT xinyancui oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT huatu oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT jiajia oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT baikechen oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT xiaohandai oralsubmucousfibrosispathogenesisandtherapeuticapproaches AT oushengliu oralsubmucousfibrosispathogenesisandtherapeuticapproaches |