Host RNA-Binding Proteins as Regulators of HIV-1 Replication
RNA-binding proteins (RBPs) are cellular factors involved in every step of RNA metabolism. During HIV-1 infection, these proteins are key players in the fine-tuning of viral and host cellular and molecular pathways, including (but not limited to) viral entry, transcription, splicing, RNA modificatio...
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MDPI AG
2024-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/43 |
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| author | Sebastian Giraldo-Ocampo Fernando Valiente-Echeverría Ricardo Soto-Rifo |
| author_facet | Sebastian Giraldo-Ocampo Fernando Valiente-Echeverría Ricardo Soto-Rifo |
| author_sort | Sebastian Giraldo-Ocampo |
| collection | DOAJ |
| description | RNA-binding proteins (RBPs) are cellular factors involved in every step of RNA metabolism. During HIV-1 infection, these proteins are key players in the fine-tuning of viral and host cellular and molecular pathways, including (but not limited to) viral entry, transcription, splicing, RNA modification, translation, decay, assembly, and packaging, as well as the modulation of the antiviral response. Targeted studies have been of paramount importance in identifying and understanding the role of RNA-binding proteins that bind to HIV-1 RNAs. However, novel approaches aimed at identifying all the proteins bound to specific RNAs (RBPome), such as RNA interactome capture, have also contributed to expanding our understanding of the HIV-1 replication cycle, allowing the identification of RBPs with functions not only in viral RNA metabolism but also in cellular metabolism. Strikingly, several of the RBPs found through interactome capture are not canonical RBPs, meaning that they do not have conventional RNA-binding domains and are therefore not readily predicted as being RBPs. Further studies on the different cellular targets of HIV-1, such as subtypes of T cells or myeloid cells, or on the context (active replication versus reactivation from latency) are needed to fully elucidate the host RBPome bound to the viral RNA, which will allow researchers and clinicians to discover new therapeutic targets during active replication and provirus reactivation from latency. |
| format | Article |
| id | doaj-art-d159dfb961414024ab5f0371c4008c4b |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-d159dfb961414024ab5f0371c4008c4b2025-01-24T13:52:22ZengMDPI AGViruses1999-49152024-12-011714310.3390/v17010043Host RNA-Binding Proteins as Regulators of HIV-1 ReplicationSebastian Giraldo-Ocampo0Fernando Valiente-Echeverría1Ricardo Soto-Rifo2Laboratory of Molecular and Cellular Virology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileLaboratory of Molecular and Cellular Virology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileLaboratory of Molecular and Cellular Virology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileRNA-binding proteins (RBPs) are cellular factors involved in every step of RNA metabolism. During HIV-1 infection, these proteins are key players in the fine-tuning of viral and host cellular and molecular pathways, including (but not limited to) viral entry, transcription, splicing, RNA modification, translation, decay, assembly, and packaging, as well as the modulation of the antiviral response. Targeted studies have been of paramount importance in identifying and understanding the role of RNA-binding proteins that bind to HIV-1 RNAs. However, novel approaches aimed at identifying all the proteins bound to specific RNAs (RBPome), such as RNA interactome capture, have also contributed to expanding our understanding of the HIV-1 replication cycle, allowing the identification of RBPs with functions not only in viral RNA metabolism but also in cellular metabolism. Strikingly, several of the RBPs found through interactome capture are not canonical RBPs, meaning that they do not have conventional RNA-binding domains and are therefore not readily predicted as being RBPs. Further studies on the different cellular targets of HIV-1, such as subtypes of T cells or myeloid cells, or on the context (active replication versus reactivation from latency) are needed to fully elucidate the host RBPome bound to the viral RNA, which will allow researchers and clinicians to discover new therapeutic targets during active replication and provirus reactivation from latency.https://www.mdpi.com/1999-4915/17/1/43HIV-1RNA-binding proteinsRBPomeRNA metabolism |
| spellingShingle | Sebastian Giraldo-Ocampo Fernando Valiente-Echeverría Ricardo Soto-Rifo Host RNA-Binding Proteins as Regulators of HIV-1 Replication Viruses HIV-1 RNA-binding proteins RBPome RNA metabolism |
| title | Host RNA-Binding Proteins as Regulators of HIV-1 Replication |
| title_full | Host RNA-Binding Proteins as Regulators of HIV-1 Replication |
| title_fullStr | Host RNA-Binding Proteins as Regulators of HIV-1 Replication |
| title_full_unstemmed | Host RNA-Binding Proteins as Regulators of HIV-1 Replication |
| title_short | Host RNA-Binding Proteins as Regulators of HIV-1 Replication |
| title_sort | host rna binding proteins as regulators of hiv 1 replication |
| topic | HIV-1 RNA-binding proteins RBPome RNA metabolism |
| url | https://www.mdpi.com/1999-4915/17/1/43 |
| work_keys_str_mv | AT sebastiangiraldoocampo hostrnabindingproteinsasregulatorsofhiv1replication AT fernandovalienteecheverria hostrnabindingproteinsasregulatorsofhiv1replication AT ricardosotorifo hostrnabindingproteinsasregulatorsofhiv1replication |