Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage Form
A simple and sensitive extractive spectrophometric method has been described for the assay of oxaprozin (OXA) either in pure form or in pharmaceutical solid dosage form. The developed method involves formation of colored chloroform extractable ion-pair complex of OXA with bromocresol green in aqueou...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/734160 |
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| author | M. Ganesh B. Thangabalan Rahul Patil Swastika Ganguly T. Sivakumar |
| author_facet | M. Ganesh B. Thangabalan Rahul Patil Swastika Ganguly T. Sivakumar |
| author_sort | M. Ganesh |
| collection | DOAJ |
| description | A simple and sensitive extractive spectrophometric method has been described for the assay of oxaprozin (OXA) either in pure form or in pharmaceutical solid dosage form. The developed method involves formation of colored chloroform extractable ion-pair complex of OXA with bromocresol green in aqueous acidic medium. The extracted complexes showed absorbance maxima at 421 nm. Beer's law is obeyed in the concentration range of 10-50 μg mL-1. This method has been applied to the determination of drug in commercial tablets. Results of analysis were validated statistically. The excipients present in the formulations do not interfere with the assay procedure. |
| format | Article |
| id | doaj-art-d144d25b12af4545908ebd9de0c5bc52 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-d144d25b12af4545908ebd9de0c5bc522025-02-03T07:25:47ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015359359710.1155/2008/734160Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage FormM. Ganesh0B. Thangabalan1Rahul Patil2Swastika Ganguly3T. Sivakumar4Department of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaDepartment of Pharmacy, Donbosco PG College, Verticherukurumandal, Guntur-522017(A.P), IndiaDepartment of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaDepartment of Pharmaceutical Sci, BIT-Mesra, Ranchi, IndiaDepartment of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, IndiaA simple and sensitive extractive spectrophometric method has been described for the assay of oxaprozin (OXA) either in pure form or in pharmaceutical solid dosage form. The developed method involves formation of colored chloroform extractable ion-pair complex of OXA with bromocresol green in aqueous acidic medium. The extracted complexes showed absorbance maxima at 421 nm. Beer's law is obeyed in the concentration range of 10-50 μg mL-1. This method has been applied to the determination of drug in commercial tablets. Results of analysis were validated statistically. The excipients present in the formulations do not interfere with the assay procedure.http://dx.doi.org/10.1155/2008/734160 |
| spellingShingle | M. Ganesh B. Thangabalan Rahul Patil Swastika Ganguly T. Sivakumar Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage Form E-Journal of Chemistry |
| title | Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage Form |
| title_full | Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage Form |
| title_fullStr | Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage Form |
| title_full_unstemmed | Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage Form |
| title_short | Simple Extractive Colorimetric Determination of Oxaprozin by Acid-Dye Complexation Methods in Solid Dosage Form |
| title_sort | simple extractive colorimetric determination of oxaprozin by acid dye complexation methods in solid dosage form |
| url | http://dx.doi.org/10.1155/2008/734160 |
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