Cancer in myositis
There is an intriguing relationship between cancer and myositis. The immunosuppressive agents commonly used to treat myositis patients are known to favor the development of cancer, but this factor does not seem to be the main cause of the association. Most myositis patients who develop cancer are co...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=131;epage=136;aulast=Selva-O'Callaghan |
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| author | Albert Selva-O'Callaghan Maria Terrones-Peinador Joana Rita Marques-Soares Albert Gil-Vila |
| author_facet | Albert Selva-O'Callaghan Maria Terrones-Peinador Joana Rita Marques-Soares Albert Gil-Vila |
| author_sort | Albert Selva-O'Callaghan |
| collection | DOAJ |
| description | There is an intriguing relationship between cancer and myositis. The immunosuppressive agents commonly used to treat myositis patients are known to favor the development of cancer, but this factor does not seem to be the main cause of the association. Most myositis patients who develop cancer are considered to have cancer-associated myositis, which suggests that there are some types of etiopathogenic relationship between these two conditions. The malignancy usually appears within 3 years of the myositis diagnosis, and the risk of cancer depends on the myositis phenotype, with classic or amyopathic dermatomyositis (DM) and immune-mediated necrotizing myopathy being the main associated phenotypes. Several considerations regarding the pathogenesis of this association and strategies to detect occult malignancy in these patients are discussed here, with special emphasis on the role of autoantibodies as markers of this condition. Anti- TIF1g (Transcription Intermediary Factor 1 gamma) antibodies have been extensively studied in patients with cancer-associated DM. In addition, we discuss the peculiarities of treating patients with cancer-associated myositis and suggest some good treatment options, and finally, we examine the cancer–myositis relationship with regard to the recently described concept of myositis as an immune-related adverse event derived from the use of checkpoint immune inhibitors to treat cancer. |
| format | Article |
| id | doaj-art-d1427e0d945b46f9a5bda8b7ae82cae5 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-d1427e0d945b46f9a5bda8b7ae82cae52025-02-03T12:00:44ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115613113610.4103/injr.injr_168_20Cancer in myositisAlbert Selva-O'CallaghanMaria Terrones-PeinadorJoana Rita Marques-SoaresAlbert Gil-VilaThere is an intriguing relationship between cancer and myositis. The immunosuppressive agents commonly used to treat myositis patients are known to favor the development of cancer, but this factor does not seem to be the main cause of the association. Most myositis patients who develop cancer are considered to have cancer-associated myositis, which suggests that there are some types of etiopathogenic relationship between these two conditions. The malignancy usually appears within 3 years of the myositis diagnosis, and the risk of cancer depends on the myositis phenotype, with classic or amyopathic dermatomyositis (DM) and immune-mediated necrotizing myopathy being the main associated phenotypes. Several considerations regarding the pathogenesis of this association and strategies to detect occult malignancy in these patients are discussed here, with special emphasis on the role of autoantibodies as markers of this condition. Anti- TIF1g (Transcription Intermediary Factor 1 gamma) antibodies have been extensively studied in patients with cancer-associated DM. In addition, we discuss the peculiarities of treating patients with cancer-associated myositis and suggest some good treatment options, and finally, we examine the cancer–myositis relationship with regard to the recently described concept of myositis as an immune-related adverse event derived from the use of checkpoint immune inhibitors to treat cancer.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=131;epage=136;aulast=Selva-O'Callaghananti-tif1gcancer-associated myositisdermatomyositisimmune-mediated necrotizing myopathy |
| spellingShingle | Albert Selva-O'Callaghan Maria Terrones-Peinador Joana Rita Marques-Soares Albert Gil-Vila Cancer in myositis Indian Journal of Rheumatology anti-tif1g cancer-associated myositis dermatomyositis immune-mediated necrotizing myopathy |
| title | Cancer in myositis |
| title_full | Cancer in myositis |
| title_fullStr | Cancer in myositis |
| title_full_unstemmed | Cancer in myositis |
| title_short | Cancer in myositis |
| title_sort | cancer in myositis |
| topic | anti-tif1g cancer-associated myositis dermatomyositis immune-mediated necrotizing myopathy |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=131;epage=136;aulast=Selva-O'Callaghan |
| work_keys_str_mv | AT albertselvaocallaghan cancerinmyositis AT mariaterronespeinador cancerinmyositis AT joanaritamarquessoares cancerinmyositis AT albertgilvila cancerinmyositis |