Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid wi...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/124762 |
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| author | Agnieszka Krupa Marek Fol Bozena R. Dziadek Ewa Kepka Dominika Wojciechowska Anna Brzostek Agnieszka Torzewska Jaroslaw Dziadek Robert P. Baughman David Griffith Anna K. Kurdowska |
| author_facet | Agnieszka Krupa Marek Fol Bozena R. Dziadek Ewa Kepka Dominika Wojciechowska Anna Brzostek Agnieszka Torzewska Jaroslaw Dziadek Robert P. Baughman David Griffith Anna K. Kurdowska |
| author_sort | Agnieszka Krupa |
| collection | DOAJ |
| description | Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M. tb); however, the underlying mechanism remains largely unknown. The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB. We have shown for the first time that IL-8 can directly bind to tubercle bacilli. We have also demonstrated that association of IL-8 with M. tb molecules leads to the augmentation of the ability of leukocytes (neutrophils and macrophages) to phagocyte and kill these bacilli. In addition, we have shown that significant amount of IL-8 present in the blood of TB patients associates with erythrocytes. Finally, we have noted that IL-8 is the major chemokine responsible for recruiting T lymphocytes (CD3+, CD4+, and CD8+ T cells). In summary, our data suggest that the association of IL-8 with M. tb molecules may modify and possibly enhance the innate immune response in patients with TB. |
| format | Article |
| id | doaj-art-d134461b62d447c6afd185eba5c851e4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d134461b62d447c6afd185eba5c851e42025-02-03T05:59:56ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/124762124762Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune ResponseAgnieszka Krupa0Marek Fol1Bozena R. Dziadek2Ewa Kepka3Dominika Wojciechowska4Anna Brzostek5Agnieszka Torzewska6Jaroslaw Dziadek7Robert P. Baughman8David Griffith9Anna K. Kurdowska10Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USADepartment of Immunology and Infectious Biology, University of Lodz, 90-237 Lodz, PolandDepartment of Immunoparasitology, University of Lodz, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, University of Lodz, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, University of Lodz, 90-237 Lodz, PolandInstitute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, PolandDepartment of Immunobiology of Bacteria, University of Lodz, 90-237 Lodz, PolandInstitute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, PolandDepartment of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45219, USADepartment of Medicine, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USADepartment of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USAInterleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M. tb); however, the underlying mechanism remains largely unknown. The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB. We have shown for the first time that IL-8 can directly bind to tubercle bacilli. We have also demonstrated that association of IL-8 with M. tb molecules leads to the augmentation of the ability of leukocytes (neutrophils and macrophages) to phagocyte and kill these bacilli. In addition, we have shown that significant amount of IL-8 present in the blood of TB patients associates with erythrocytes. Finally, we have noted that IL-8 is the major chemokine responsible for recruiting T lymphocytes (CD3+, CD4+, and CD8+ T cells). In summary, our data suggest that the association of IL-8 with M. tb molecules may modify and possibly enhance the innate immune response in patients with TB.http://dx.doi.org/10.1155/2015/124762 |
| spellingShingle | Agnieszka Krupa Marek Fol Bozena R. Dziadek Ewa Kepka Dominika Wojciechowska Anna Brzostek Agnieszka Torzewska Jaroslaw Dziadek Robert P. Baughman David Griffith Anna K. Kurdowska Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response Mediators of Inflammation |
| title | Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response |
| title_full | Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response |
| title_fullStr | Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response |
| title_full_unstemmed | Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response |
| title_short | Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response |
| title_sort | binding of cxcl8 il 8 to mycobacterium tuberculosis modulates the innate immune response |
| url | http://dx.doi.org/10.1155/2015/124762 |
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