Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis
The local production of tumour necrosis factor-α (TNFα) was evaluated in the cerebrospinal fluid (CSF) from ten patients with tuberculous meningitis (TBM). The degree of intrathecal immune activation was also studied by assessing the CSF levels of β2-microglobulin (β2-M) and adenosine deaminase acti...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000104 |
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| author | C. M. Mastroianni F. Paoletti C. Valenti A. P. Massetti V. Vullo S. Delia |
| author_facet | C. M. Mastroianni F. Paoletti C. Valenti A. P. Massetti V. Vullo S. Delia |
| author_sort | C. M. Mastroianni |
| collection | DOAJ |
| description | The local production of tumour necrosis factor-α (TNFα)
was evaluated in the cerebrospinal fluid (CSF) from ten patients
with tuberculous meningitis (TBM). The degree of intrathecal immune
activation was also studied by assessing the CSF levels of
β2-microglobulin (β2-M) and
adenosine deaminase activity (ADA). Results indicate that elevated
CSF concentrations of TNFα, β2-M and ADA were
found in all TBM patients. Moreover, TNFα is produced and
selectively concentrated for a long period of time, while
β2-M and ADA values progressively decline during the
course of TBM. Our findings suggest that in TBM patients, after an
early activation of immune cells, there is an enhanced and
continuous production of TNFα at the site of infection. |
| format | Article |
| id | doaj-art-d131a6dbce794ada818d37a7d2324aca |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d131a6dbce794ada818d37a7d2324aca2025-02-03T05:54:17ZengWileyMediators of Inflammation0962-93511466-18611994-01-0131576010.1155/S0962935194000104Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous MeningitisC. M. Mastroianni0F. Paoletti1C. Valenti2A. P. Massetti3V. Vullo4S. Delia5Institute of Infectious Diseases, University La Sapienza, Policlinico Umberto I, Viale Regina Elena 331, Rome 00161, ItalyInstitute of Infectious Diseases, University La Sapienza, Policlinico Umberto I, Viale Regina Elena 331, Rome 00161, ItalyInstitute of Infectious Diseases, University La Sapienza, Policlinico Umberto I, Viale Regina Elena 331, Rome 00161, ItalyInstitute of Infectious Diseases, University La Sapienza, Policlinico Umberto I, Viale Regina Elena 331, Rome 00161, ItalyInstitute of Infectious Diseases, University La Sapienza, Policlinico Umberto I, Viale Regina Elena 331, Rome 00161, ItalyInstitute of Infectious Diseases, University La Sapienza, Policlinico Umberto I, Viale Regina Elena 331, Rome 00161, ItalyThe local production of tumour necrosis factor-α (TNFα) was evaluated in the cerebrospinal fluid (CSF) from ten patients with tuberculous meningitis (TBM). The degree of intrathecal immune activation was also studied by assessing the CSF levels of β2-microglobulin (β2-M) and adenosine deaminase activity (ADA). Results indicate that elevated CSF concentrations of TNFα, β2-M and ADA were found in all TBM patients. Moreover, TNFα is produced and selectively concentrated for a long period of time, while β2-M and ADA values progressively decline during the course of TBM. Our findings suggest that in TBM patients, after an early activation of immune cells, there is an enhanced and continuous production of TNFα at the site of infection.http://dx.doi.org/10.1155/S0962935194000104 |
| spellingShingle | C. M. Mastroianni F. Paoletti C. Valenti A. P. Massetti V. Vullo S. Delia Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis Mediators of Inflammation |
| title | Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis |
| title_full | Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis |
| title_fullStr | Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis |
| title_full_unstemmed | Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis |
| title_short | Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis |
| title_sort | tumour necrosis factor α production and immune cell activation in tuberculous meningitis |
| url | http://dx.doi.org/10.1155/S0962935194000104 |
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