Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis
The local production of tumour necrosis factor-α (TNFα) was evaluated in the cerebrospinal fluid (CSF) from ten patients with tuberculous meningitis (TBM). The degree of intrathecal immune activation was also studied by assessing the CSF levels of β2-microglobulin (β2-M) and adenosine deaminase acti...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000104 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The local production of tumour necrosis factor-α (TNFα)
was evaluated in the cerebrospinal fluid (CSF) from ten patients
with tuberculous meningitis (TBM). The degree of intrathecal immune
activation was also studied by assessing the CSF levels of
β2-microglobulin (β2-M) and
adenosine deaminase activity (ADA). Results indicate that elevated
CSF concentrations of TNFα, β2-M and ADA were
found in all TBM patients. Moreover, TNFα is produced and
selectively concentrated for a long period of time, while
β2-M and ADA values progressively decline during the
course of TBM. Our findings suggest that in TBM patients, after an
early activation of immune cells, there is an enhanced and
continuous production of TNFα at the site of infection. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |