Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Multiple organ failure in SLE can be caused by immune dysfunction and deposition of autoantibodies. Studies of SLE-susceptible loci and the cellular and humoral imm...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/478429 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565202787237888 |
|---|---|
| author | Yi-Ping Chuang Chih-Hung Wang Ning-Chi Wang Deh-Ming Chang Huey-Kang Sytwu |
| author_facet | Yi-Ping Chuang Chih-Hung Wang Ning-Chi Wang Deh-Ming Chang Huey-Kang Sytwu |
| author_sort | Yi-Ping Chuang |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Multiple organ failure in SLE can be caused by immune dysfunction and deposition of autoantibodies. Studies of SLE-susceptible loci and the cellular and humoral immune responses reveal variable aberrations associated with this systemic disease. Invariant natural killer T (iNKT) cells are a unique subset of lymphocytes that control peripheral tolerance. Mounting evidence showing reductions in the proportion and activity of iNKT cells in SLE patients suggests the suppressive role of iNKT cells. Studies using murine lupus models demonstrate that iNKT cells participate in SLE progression by sensing apoptotic cells, regulating immunoglobulin production, and altering the cytokine profile upon activation. However, the dichotomy of iNKT cell actions in murine models implies complicated interactions within the body's milieu. Therefore, application of potential therapy for SLE using glycolipids to regulate iNKT cells should be undertaken cautiously. |
| format | Article |
| id | doaj-art-d12339a3abdb4fa09e2a41ca0d032fd3 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d12339a3abdb4fa09e2a41ca0d032fd32025-02-03T01:09:08ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/478429478429Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus ErythematosusYi-Ping Chuang0Chih-Hung Wang1Ning-Chi Wang2Deh-Ming Chang3Huey-Kang Sytwu4Department of Microbiology and Immunology, National Defense Medical Center, Taipei 114, TaiwanDepartment of Otolaryngology-Head & Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, Taipei 114, TaiwanDepartment of Internal Medicine, Tri-Service General Hospital, Taipei 114, TaiwanDepartment of Microbiology and Immunology, National Defense Medical Center, Taipei 114, TaiwanSystemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Multiple organ failure in SLE can be caused by immune dysfunction and deposition of autoantibodies. Studies of SLE-susceptible loci and the cellular and humoral immune responses reveal variable aberrations associated with this systemic disease. Invariant natural killer T (iNKT) cells are a unique subset of lymphocytes that control peripheral tolerance. Mounting evidence showing reductions in the proportion and activity of iNKT cells in SLE patients suggests the suppressive role of iNKT cells. Studies using murine lupus models demonstrate that iNKT cells participate in SLE progression by sensing apoptotic cells, regulating immunoglobulin production, and altering the cytokine profile upon activation. However, the dichotomy of iNKT cell actions in murine models implies complicated interactions within the body's milieu. Therefore, application of potential therapy for SLE using glycolipids to regulate iNKT cells should be undertaken cautiously.http://dx.doi.org/10.1155/2012/478429 |
| spellingShingle | Yi-Ping Chuang Chih-Hung Wang Ning-Chi Wang Deh-Ming Chang Huey-Kang Sytwu Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus Clinical and Developmental Immunology |
| title | Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus |
| title_full | Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus |
| title_fullStr | Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus |
| title_full_unstemmed | Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus |
| title_short | Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus |
| title_sort | modulatory function of invariant natural killer t cells in systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2012/478429 |
| work_keys_str_mv | AT yipingchuang modulatoryfunctionofinvariantnaturalkillertcellsinsystemiclupuserythematosus AT chihhungwang modulatoryfunctionofinvariantnaturalkillertcellsinsystemiclupuserythematosus AT ningchiwang modulatoryfunctionofinvariantnaturalkillertcellsinsystemiclupuserythematosus AT dehmingchang modulatoryfunctionofinvariantnaturalkillertcellsinsystemiclupuserythematosus AT hueykangsytwu modulatoryfunctionofinvariantnaturalkillertcellsinsystemiclupuserythematosus |