Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/274643 |
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| author | Larissa Lavorato Lima Rebeca Mól Lima Annelisa Farah da Silva Antônio Márcio Resende do Carmo Adilson David da Silva Nádia Rezende Barbosa Raposo |
| author_facet | Larissa Lavorato Lima Rebeca Mól Lima Annelisa Farah da Silva Antônio Márcio Resende do Carmo Adilson David da Silva Nádia Rezende Barbosa Raposo |
| author_sort | Larissa Lavorato Lima |
| collection | DOAJ |
| description | This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50 = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P<0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring. |
| format | Article |
| id | doaj-art-d11a3f47fe2d4d3caa1dc4727070352e |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d11a3f47fe2d4d3caa1dc4727070352e2025-02-03T01:24:15ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/274643274643Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting PotentialLarissa Lavorato Lima0Rebeca Mól Lima1Annelisa Farah da Silva2Antônio Márcio Resende do Carmo3Adilson David da Silva4Nádia Rezende Barbosa Raposo5Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, BrazilNúcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, BrazilNúcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, BrazilFaculdade de Odontologia, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, BrazilNúcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, BrazilThis research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50 = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P<0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.http://dx.doi.org/10.1155/2013/274643 |
| spellingShingle | Larissa Lavorato Lima Rebeca Mól Lima Annelisa Farah da Silva Antônio Márcio Resende do Carmo Adilson David da Silva Nádia Rezende Barbosa Raposo Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential The Scientific World Journal |
| title | Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential |
| title_full | Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential |
| title_fullStr | Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential |
| title_full_unstemmed | Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential |
| title_short | Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential |
| title_sort | azastilbene analogs as tyrosinase inhibitors new molecules with depigmenting potential |
| url | http://dx.doi.org/10.1155/2013/274643 |
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