Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization
Rational pharmacotherapy is understood as intelligent drug combination and dosage adjustment for the purpose of drug adverse events development risk minimization and achievement of suitable therapeutical effect. One of the main factors affecting on drug potency is activity of biotransformation syste...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2020-04-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/158 |
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| author | E. . Egorenkov V. . Smirnov A. . Litvin G. . Kolyvanov G. . Ramenskaya |
| author_facet | E. . Egorenkov V. . Smirnov A. . Litvin G. . Kolyvanov G. . Ramenskaya |
| author_sort | E. . Egorenkov |
| collection | DOAJ |
| description | Rational pharmacotherapy is understood as intelligent drug combination and dosage adjustment for the purpose of drug adverse events development risk minimization and achievement of suitable therapeutical effect. One of the main factors affecting on drug potency is activity of biotransformation system. In this work, a review of promising "cocktail" method of biotransformation enzymes activity determination in vivo is given. |
| format | Article |
| id | doaj-art-d110184770eb4700a8d591ebfb65b89e |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2020-04-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-d110184770eb4700a8d591ebfb65b89e2025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302020-04-01013337157Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalizationE. . Egorenkov0V. . Smirnov1A. . Litvin2G. . Kolyvanov3G. . Ramenskaya4I.M. Sechenov First Moscow State Medical University; National Research Center Institute of Immunology Federal Medical Biological Agency of RussiaI.M. Sechenov First Moscow State Medical University; National Research Center Institute of Immunology Federal Medical Biological Agency of Russia; FSBI «Scientific Centre for Expert Evaluation of Medical Products» of the Ministry of Health of the Russian FederationFSBSI «Zakusov Institute of Pharmacology»FSBSI «Zakusov Institute of Pharmacology»I.M. Sechenov First Moscow State Medical University; FSBI «Scientific Centre for Expert Evaluation of Medical Products» of the Ministry of Health of the Russian FederationRational pharmacotherapy is understood as intelligent drug combination and dosage adjustment for the purpose of drug adverse events development risk minimization and achievement of suitable therapeutical effect. One of the main factors affecting on drug potency is activity of biotransformation system. In this work, a review of promising "cocktail" method of biotransformation enzymes activity determination in vivo is given.https://www.pharmacokinetica.ru/jour/article/view/158цитохром p450cyp«коктейльный» методперсонализированная медицинарациональная фармакотерапияcytochrome p450cyp«cocktail» approachpersonalized medicinerational pharmacotherapy |
| spellingShingle | E. . Egorenkov V. . Smirnov A. . Litvin G. . Kolyvanov G. . Ramenskaya Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization Фармакокинетика и Фармакодинамика цитохром p450 cyp «коктейльный» метод персонализированная медицина рациональная фармакотерапия cytochrome p450 cyp «cocktail» approach personalized medicine rational pharmacotherapy |
| title | Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization |
| title_full | Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization |
| title_fullStr | Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization |
| title_full_unstemmed | Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization |
| title_short | Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization |
| title_sort | aspects of cocktail cytochrome p450 activity determination methods application with the view of drug treatment rationalization |
| topic | цитохром p450 cyp «коктейльный» метод персонализированная медицина рациональная фармакотерапия cytochrome p450 cyp «cocktail» approach personalized medicine rational pharmacotherapy |
| url | https://www.pharmacokinetica.ru/jour/article/view/158 |
| work_keys_str_mv | AT eegorenkov aspectsofcocktailcytochromep450activitydeterminationmethodsapplicationwiththeviewofdrugtreatmentrationalization AT vsmirnov aspectsofcocktailcytochromep450activitydeterminationmethodsapplicationwiththeviewofdrugtreatmentrationalization AT alitvin aspectsofcocktailcytochromep450activitydeterminationmethodsapplicationwiththeviewofdrugtreatmentrationalization AT gkolyvanov aspectsofcocktailcytochromep450activitydeterminationmethodsapplicationwiththeviewofdrugtreatmentrationalization AT gramenskaya aspectsofcocktailcytochromep450activitydeterminationmethodsapplicationwiththeviewofdrugtreatmentrationalization |