Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population
Abstract To evaluate the incidence and risk of cardiovascular disease (CVD) among Korean patients with systemic lupus erythematosus (SLE) comparing them to diabetes patients and the general population. This nationwide cohort study focused on incident SLE patients aged over 40 years, matched with dia...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87740-y |
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| author | Jung-Yong Han Soo-Kyung Cho Yena Jeon Gaeun Kang Sun-Young Jung Eun Jin Jang Yoon-Kyoung Sung |
| author_facet | Jung-Yong Han Soo-Kyung Cho Yena Jeon Gaeun Kang Sun-Young Jung Eun Jin Jang Yoon-Kyoung Sung |
| author_sort | Jung-Yong Han |
| collection | DOAJ |
| description | Abstract To evaluate the incidence and risk of cardiovascular disease (CVD) among Korean patients with systemic lupus erythematosus (SLE) comparing them to diabetes patients and the general population. This nationwide cohort study focused on incident SLE patients aged over 40 years, matched with diabetes patients and the general population (1:4:4 ratio). CVD was defined as ischaemic heart disease, ischaemic stroke, and cardiac arrest. Incidence rate and incidence rate ratio (IRR) of CVD were calculated using generalised estimating equation models. The Fine-Gray model assessed risk factors for CVD in both SLE and diabetes patients. The study included 4272 incident SLE patients, 17,003 diabetes patients, and 17,088 from the general population. SLE patients had higher CVD risk compared to the general population, with adjusted IRRs of 1.99 for overall CVD. Diabetes patients showed increased CVD risk, but to a lesser extent, with an IRR of 1.39. SLE patients aged 40–59 years displayed a significantly elevated CVD risk. Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. SLE patients have a higher risk of CVD compared to the general population, more so than diabetes patients. |
| format | Article |
| id | doaj-art-d1033b36cfc14d2caa1951a60f1a340e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d1033b36cfc14d2caa1951a60f1a340e2025-01-26T12:32:56ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-87740-yCardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general populationJung-Yong Han0Soo-Kyung Cho1Yena Jeon2Gaeun Kang3Sun-Young Jung4Eun Jin Jang5Yoon-Kyoung Sung6Department of Rheumatology, Hanyang University Hospital for Rheumatic DiseasesDepartment of Rheumatology, Hanyang University Hospital for Rheumatic DiseasesDepartment of Statistics, Kyungpook National UniversityDepartment of Statistics, Kyungpook National UniversityCollege of Pharmacy, Chung-Ang UniversityDepartment of Information Statistics, Andong National UniversityDepartment of Rheumatology, Hanyang University Hospital for Rheumatic DiseasesAbstract To evaluate the incidence and risk of cardiovascular disease (CVD) among Korean patients with systemic lupus erythematosus (SLE) comparing them to diabetes patients and the general population. This nationwide cohort study focused on incident SLE patients aged over 40 years, matched with diabetes patients and the general population (1:4:4 ratio). CVD was defined as ischaemic heart disease, ischaemic stroke, and cardiac arrest. Incidence rate and incidence rate ratio (IRR) of CVD were calculated using generalised estimating equation models. The Fine-Gray model assessed risk factors for CVD in both SLE and diabetes patients. The study included 4272 incident SLE patients, 17,003 diabetes patients, and 17,088 from the general population. SLE patients had higher CVD risk compared to the general population, with adjusted IRRs of 1.99 for overall CVD. Diabetes patients showed increased CVD risk, but to a lesser extent, with an IRR of 1.39. SLE patients aged 40–59 years displayed a significantly elevated CVD risk. Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. SLE patients have a higher risk of CVD compared to the general population, more so than diabetes patients.https://doi.org/10.1038/s41598-025-87740-ySystemic lupus erythematosusCardiovascular diseaseDiabetes mellitus |
| spellingShingle | Jung-Yong Han Soo-Kyung Cho Yena Jeon Gaeun Kang Sun-Young Jung Eun Jin Jang Yoon-Kyoung Sung Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population Scientific Reports Systemic lupus erythematosus Cardiovascular disease Diabetes mellitus |
| title | Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population |
| title_full | Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population |
| title_fullStr | Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population |
| title_full_unstemmed | Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population |
| title_short | Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population |
| title_sort | cardiovascular disease risk in korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population |
| topic | Systemic lupus erythematosus Cardiovascular disease Diabetes mellitus |
| url | https://doi.org/10.1038/s41598-025-87740-y |
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