Clinical analysis of molecular typing of 146 cases of endometrial carcinoma
ObjectiveTo investigate the application of TCGA molecular typing in endometrial carcinoma, compare the relationship between molecular typing and clinicopathologic features, and provide a new idea for individual treatment of patients.MethodsA total of 146 EC patients who underwent surgical treatment...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1482817/full |
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| author | Bo Zhang Bo Zhang Dan Zhou Shuo Zhang Jinbowen Yan Qingwei Meng Qiubo Lv |
| author_facet | Bo Zhang Bo Zhang Dan Zhou Shuo Zhang Jinbowen Yan Qingwei Meng Qiubo Lv |
| author_sort | Bo Zhang |
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| description | ObjectiveTo investigate the application of TCGA molecular typing in endometrial carcinoma, compare the relationship between molecular typing and clinicopathologic features, and provide a new idea for individual treatment of patients.MethodsA total of 146 EC patients who underwent surgical treatment and TCGA molecular typing in Beijing Hospital from December 2019 to March 2023 were collected. The clinicopathologic features, immunohistochemistry, and prognosis of the four TCGA molecular types were analyzed retrospectively.ResultAmong the 146 patients with endometrial cancer (EC), 8 patients (5.5%) exhibited the POLE hypermutant type, 29 patients (19.9%) displayed the MSI-H type, 94 patients (64.4%) presented the low copy-number type, and 15 patients (10.3%) manifested the high copy-number type. A comparative analysis of the four TCGA types and age yielded statistically significant results (p = 0.012). Notably, significant associations were observed between menopausal status, the expression of ER, PR, and the four TCGA types. However, no significant difference was observed in CA125 levels before surgery among the four TCGA types (p = 0.587). There were significant differences observed among the four TCGA types and pathological types, pathological grades, FIGO stage, lymph node metastasis, and LVSI. The progression-free survival (PFS) rates of patients with POLE hypermutation, MSI-H type, CNL type, and CNH type were 100%, 100%, 93.62%, and 73.3%, respectively. There was a statistically significant difference between the four groups(p=0.006). POLE mutant and MSI-H type patients have higher PFS, while high copy type patients have the lowest.ConclusionsTCGA molecular typing has feasibility and application value in the clinical application of endometrial cancer, and has a certain predictive effect on the prognosis of EC patients. It has a certain guiding significance for the individual treatment of patients with endometrial cancer. |
| format | Article |
| id | doaj-art-d0feeacdf31a48bdbafccbc68b0b7e11 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-d0feeacdf31a48bdbafccbc68b0b7e112025-01-20T05:23:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14828171482817Clinical analysis of molecular typing of 146 cases of endometrial carcinomaBo Zhang0Bo Zhang1Dan Zhou2Shuo Zhang3Jinbowen Yan4Qingwei Meng5Qiubo Lv6Department of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Dongdan, Beijing, ChinaChinese Academy of Medical Sciences and Peking Union Medical College, Beijing Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Dongdan, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Dongdan, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Dongdan, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Dongdan, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Dongdan, Beijing, ChinaObjectiveTo investigate the application of TCGA molecular typing in endometrial carcinoma, compare the relationship between molecular typing and clinicopathologic features, and provide a new idea for individual treatment of patients.MethodsA total of 146 EC patients who underwent surgical treatment and TCGA molecular typing in Beijing Hospital from December 2019 to March 2023 were collected. The clinicopathologic features, immunohistochemistry, and prognosis of the four TCGA molecular types were analyzed retrospectively.ResultAmong the 146 patients with endometrial cancer (EC), 8 patients (5.5%) exhibited the POLE hypermutant type, 29 patients (19.9%) displayed the MSI-H type, 94 patients (64.4%) presented the low copy-number type, and 15 patients (10.3%) manifested the high copy-number type. A comparative analysis of the four TCGA types and age yielded statistically significant results (p = 0.012). Notably, significant associations were observed between menopausal status, the expression of ER, PR, and the four TCGA types. However, no significant difference was observed in CA125 levels before surgery among the four TCGA types (p = 0.587). There were significant differences observed among the four TCGA types and pathological types, pathological grades, FIGO stage, lymph node metastasis, and LVSI. The progression-free survival (PFS) rates of patients with POLE hypermutation, MSI-H type, CNL type, and CNH type were 100%, 100%, 93.62%, and 73.3%, respectively. There was a statistically significant difference between the four groups(p=0.006). POLE mutant and MSI-H type patients have higher PFS, while high copy type patients have the lowest.ConclusionsTCGA molecular typing has feasibility and application value in the clinical application of endometrial cancer, and has a certain predictive effect on the prognosis of EC patients. It has a certain guiding significance for the individual treatment of patients with endometrial cancer.https://www.frontiersin.org/articles/10.3389/fonc.2024.1482817/fullendometrial cancermolecular typingclinical analysisthe prognosisindividual treatment |
| spellingShingle | Bo Zhang Bo Zhang Dan Zhou Shuo Zhang Jinbowen Yan Qingwei Meng Qiubo Lv Clinical analysis of molecular typing of 146 cases of endometrial carcinoma Frontiers in Oncology endometrial cancer molecular typing clinical analysis the prognosis individual treatment |
| title | Clinical analysis of molecular typing of 146 cases of endometrial carcinoma |
| title_full | Clinical analysis of molecular typing of 146 cases of endometrial carcinoma |
| title_fullStr | Clinical analysis of molecular typing of 146 cases of endometrial carcinoma |
| title_full_unstemmed | Clinical analysis of molecular typing of 146 cases of endometrial carcinoma |
| title_short | Clinical analysis of molecular typing of 146 cases of endometrial carcinoma |
| title_sort | clinical analysis of molecular typing of 146 cases of endometrial carcinoma |
| topic | endometrial cancer molecular typing clinical analysis the prognosis individual treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1482817/full |
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