Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes
Tripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) act as ACE inhibitors in vitro. Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation. The present study was aimed to eval...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2010/287030 |
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| author | Tiina Jauhiainen Taru Pilvi Zhong Jian Cheng Hannu Kautiainen Dominik N. Müller Heikki Vapaatalo Riitta Korpela Eero Mervaala |
| author_facet | Tiina Jauhiainen Taru Pilvi Zhong Jian Cheng Hannu Kautiainen Dominik N. Müller Heikki Vapaatalo Riitta Korpela Eero Mervaala |
| author_sort | Tiina Jauhiainen |
| collection | DOAJ |
| description | Tripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) act as ACE inhibitors in vitro. Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation. The present study was aimed to evaluate possible antihypertensive effect of IPP and VPP in this severe model. Four-week-old dTGR were randomized in three groups to receive: (1) water (control), (2) fermented milk containing IPP and VPP, and (3) IPP and VPP dissolved in water for three weeks. Fermented milk, but not peptides in water, attenuated the development of hypertension in dTGR by 19 mmHg versus the control group (P=.023). In vitro vascular function tests showed that high concentrations of the peptides evinced ACE inhibitory properties. In other hypertension related variables, no significant differences between the treatment groups were found. In conclusion, fermented milk product containing IPP and VPP prevents development of malignant hypertension in an animal model. |
| format | Article |
| id | doaj-art-d0f3b5825f8546e5bbee2f45c7db48ae |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-d0f3b5825f8546e5bbee2f45c7db48ae2025-02-03T06:01:50ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322010-01-01201010.1155/2010/287030287030Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen GenesTiina Jauhiainen0Taru Pilvi1Zhong Jian Cheng2Hannu Kautiainen3Dominik N. Müller4Heikki Vapaatalo5Riitta Korpela6Eero Mervaala7Institute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, FinlandInstitute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, FinlandInstitute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, FinlandMedcare Oy, 44100 Äänekoski, FinlandMax Delbruck Center for Molecular Medicine, 13125 Berlin, GermanyInstitute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, FinlandInstitute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, FinlandInstitute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, FinlandTripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) act as ACE inhibitors in vitro. Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation. The present study was aimed to evaluate possible antihypertensive effect of IPP and VPP in this severe model. Four-week-old dTGR were randomized in three groups to receive: (1) water (control), (2) fermented milk containing IPP and VPP, and (3) IPP and VPP dissolved in water for three weeks. Fermented milk, but not peptides in water, attenuated the development of hypertension in dTGR by 19 mmHg versus the control group (P=.023). In vitro vascular function tests showed that high concentrations of the peptides evinced ACE inhibitory properties. In other hypertension related variables, no significant differences between the treatment groups were found. In conclusion, fermented milk product containing IPP and VPP prevents development of malignant hypertension in an animal model.http://dx.doi.org/10.1155/2010/287030 |
| spellingShingle | Tiina Jauhiainen Taru Pilvi Zhong Jian Cheng Hannu Kautiainen Dominik N. Müller Heikki Vapaatalo Riitta Korpela Eero Mervaala Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes Journal of Nutrition and Metabolism |
| title | Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes |
| title_full | Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes |
| title_fullStr | Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes |
| title_full_unstemmed | Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes |
| title_short | Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes |
| title_sort | milk products containing bioactive tripeptides have an antihypertensive effect in double transgenic rats dtgr harbouring human renin and human angiotensinogen genes |
| url | http://dx.doi.org/10.1155/2010/287030 |
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