Telomere length in sleep disorders
Background: Sleep and circadian rhythms are affected by aging. Although the relationship between sleep disorders and cellular aging has been demonstrated in some studies, it still remains unclear. Telomere length has been considered one of the sensitive biomarkers for aging in recent years. Studies...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525001809 |
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| author | Gülüstan Eşel Özlem Olguner Eker Ayaz Amraliyev Akif Asdemir Elif Özge Biçer Damla Badur Mermer Munis Dündar Ertuğrul Eşel Sevda İsmailoğulları |
| author_facet | Gülüstan Eşel Özlem Olguner Eker Ayaz Amraliyev Akif Asdemir Elif Özge Biçer Damla Badur Mermer Munis Dündar Ertuğrul Eşel Sevda İsmailoğulları |
| author_sort | Gülüstan Eşel |
| collection | DOAJ |
| description | Background: Sleep and circadian rhythms are affected by aging. Although the relationship between sleep disorders and cellular aging has been demonstrated in some studies, it still remains unclear. Telomere length has been considered one of the sensitive biomarkers for aging in recent years. Studies investigating the relationship between sleep disorders and telomere length are limited and their results are inconsistent. This study aims to demonstrate telomere length in sleep disorders. Methods: The study sample consisted of 116 participants, 94 patients and 22 healthy participants. Patients groups comprised diagnosed with narcolepsy (N = 31), insomnia (N = 20), Restless Legs Syndrome (RLS) (N = 21), and Obstructive Sleep Apnea Syndrome (OSAS) (N = 22) according to ICSD-3 diagnostic criteria. All participants were aged between 18‐55 and had no tobacco, alcohol, or substance dependence. Telomere lengths of the participants were measured using the rtPCR method. Results: When telomere lengths were compared across groups, no significant differences were observed between the healthy controls and any of the patient groups. However, among the patient groups, individuals with insomnia had significantly shorter telomere lengths compared to those with RLS (p = 0.014) and OSAS (p = 0.012) (F = 4.405; p = 0.002). Conclusions: The finding that patients with insomnia exhibited shorter telomeres than those with RLS and OSAS suggests that insomnia may present a higher risk for age-related diseases and accelerated aging processes. |
| format | Article |
| id | doaj-art-d0db668e80ed4d00a75a213cee785b43 |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-d0db668e80ed4d00a75a213cee785b432025-08-20T04:01:00ZengElsevierExperimental Gerontology1873-68152025-10-0120911285110.1016/j.exger.2025.112851Telomere length in sleep disordersGülüstan Eşel0Özlem Olguner Eker1Ayaz Amraliyev2Akif Asdemir3Elif Özge Biçer4Damla Badur Mermer5Munis Dündar6Ertuğrul Eşel7Sevda İsmailoğulları8Gevher Nesibe Genome and Stem Cell Institute, Erciyes University, 38030 Melikgazi, Kayseri, TurkeyDepartment of Psychiatry, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Neurology, Erciyes University Faculty of Medicine Kayseri, TurkeyDepartment of Psychiatry, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Neurology, Erciyes University Faculty of Medicine Kayseri, TurkeyDepartment of Medical Genetics, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Medical Genetics, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Psychiatry, Erciyes University Faculty of Medicine, Kayseri, TurkeyGevher Nesibe Genome and Stem Cell Institute, Erciyes University, 38030 Melikgazi, Kayseri, Turkey; Department of Neurology, Erciyes University Faculty of Medicine Kayseri, Turkey; Corresponding author at: Department of Neurology, Erciyes University Faculty of Medicine, Kayseri, Turkey.Background: Sleep and circadian rhythms are affected by aging. Although the relationship between sleep disorders and cellular aging has been demonstrated in some studies, it still remains unclear. Telomere length has been considered one of the sensitive biomarkers for aging in recent years. Studies investigating the relationship between sleep disorders and telomere length are limited and their results are inconsistent. This study aims to demonstrate telomere length in sleep disorders. Methods: The study sample consisted of 116 participants, 94 patients and 22 healthy participants. Patients groups comprised diagnosed with narcolepsy (N = 31), insomnia (N = 20), Restless Legs Syndrome (RLS) (N = 21), and Obstructive Sleep Apnea Syndrome (OSAS) (N = 22) according to ICSD-3 diagnostic criteria. All participants were aged between 18‐55 and had no tobacco, alcohol, or substance dependence. Telomere lengths of the participants were measured using the rtPCR method. Results: When telomere lengths were compared across groups, no significant differences were observed between the healthy controls and any of the patient groups. However, among the patient groups, individuals with insomnia had significantly shorter telomere lengths compared to those with RLS (p = 0.014) and OSAS (p = 0.012) (F = 4.405; p = 0.002). Conclusions: The finding that patients with insomnia exhibited shorter telomeres than those with RLS and OSAS suggests that insomnia may present a higher risk for age-related diseases and accelerated aging processes.http://www.sciencedirect.com/science/article/pii/S0531556525001809Sleep disordersTelomere lengthCellular senescence |
| spellingShingle | Gülüstan Eşel Özlem Olguner Eker Ayaz Amraliyev Akif Asdemir Elif Özge Biçer Damla Badur Mermer Munis Dündar Ertuğrul Eşel Sevda İsmailoğulları Telomere length in sleep disorders Experimental Gerontology Sleep disorders Telomere length Cellular senescence |
| title | Telomere length in sleep disorders |
| title_full | Telomere length in sleep disorders |
| title_fullStr | Telomere length in sleep disorders |
| title_full_unstemmed | Telomere length in sleep disorders |
| title_short | Telomere length in sleep disorders |
| title_sort | telomere length in sleep disorders |
| topic | Sleep disorders Telomere length Cellular senescence |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525001809 |
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