Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
Abstract The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human...
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Nature Portfolio
2024-10-01
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| Online Access: | https://doi.org/10.1038/s41598-024-76506-7 |
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| author | Yanjiao Li Jingjing Hu Jingjing Hou Shuiping Lu Jiasheng Xiong Yuxi Wang Zhong Sun Weijie Chen Yue Pan Karuppiah Thilakavathy Yi Feng Qingwu Jiang Weibing Wang Chenglong Xiong |
| author_facet | Yanjiao Li Jingjing Hu Jingjing Hou Shuiping Lu Jiasheng Xiong Yuxi Wang Zhong Sun Weijie Chen Yue Pan Karuppiah Thilakavathy Yi Feng Qingwu Jiang Weibing Wang Chenglong Xiong |
| author_sort | Yanjiao Li |
| collection | DOAJ |
| description | Abstract The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants. |
| format | Article |
| id | doaj-art-d0d41fbe98ba48e4aa1b95f30bd470a3 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d0d41fbe98ba48e4aa1b95f30bd470a32025-08-20T01:50:38ZengNature PortfolioScientific Reports2045-23222024-10-0114111110.1038/s41598-024-76506-7Study on sentinel hosts for surveillance of future COVID-19-like outbreaksYanjiao Li0Jingjing Hu1Jingjing Hou2Shuiping Lu3Jiasheng Xiong4Yuxi Wang5Zhong Sun6Weijie Chen7Yue Pan8Karuppiah Thilakavathy9Yi Feng10Qingwu Jiang11Weibing Wang12Chenglong Xiong13Department of Epidemiology, School of Public Health, Fudan UniversityDepartment of Epidemiology, School of Public Health, Fudan UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Epidemiology, School of Public Health, Fudan UniversityDivision of Emergency Management, Shanghai Municipal Center for Disease Control and PreventionDepartment of Epidemiology, School of Public Health, Fudan UniversityDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Epidemiology, School of Public Health, Fudan UniversityDepartment of Epidemiology, School of Public Health, Fudan UniversityDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan UniversityDepartment of Epidemiology, School of Public Health, Fudan UniversityDepartment of Epidemiology, School of Public Health, Fudan UniversityDepartment of Epidemiology, School of Public Health, Fudan UniversityAbstract The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants.https://doi.org/10.1038/s41598-024-76506-7SARS-CoV-2Sentinel hostSpike proteinPhylogenetic treeAmino acid polymorphismPositively selected site |
| spellingShingle | Yanjiao Li Jingjing Hu Jingjing Hou Shuiping Lu Jiasheng Xiong Yuxi Wang Zhong Sun Weijie Chen Yue Pan Karuppiah Thilakavathy Yi Feng Qingwu Jiang Weibing Wang Chenglong Xiong Study on sentinel hosts for surveillance of future COVID-19-like outbreaks Scientific Reports SARS-CoV-2 Sentinel host Spike protein Phylogenetic tree Amino acid polymorphism Positively selected site |
| title | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_full | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_fullStr | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_full_unstemmed | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_short | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_sort | study on sentinel hosts for surveillance of future covid 19 like outbreaks |
| topic | SARS-CoV-2 Sentinel host Spike protein Phylogenetic tree Amino acid polymorphism Positively selected site |
| url | https://doi.org/10.1038/s41598-024-76506-7 |
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