Chlamydia muridarum mutant CM-pGP3S as a novel attenuated live rectal vaccine protects against genital tract infection

Chlamydia muridarum mutant CM-pGP3S as a novel attenuated live rectal vaccine protects against genital tract infection

IntroductionChlamydia trachomatis (CT) is a major sexually transmitted pathogen with severe complications. Using Chlamydia muridarum (CM) as a model, this study evaluates the attenuated mutant Chlamydia muridarum (CM-pGP3S) as a novel rectal vaccine to protect against genital tract infection and pat...

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Bibliographic Details
Main Authors: Jingyue Ma, Tianyuan Zhang, Qi Tian, Meng Xiao, Long Han, Quanzhong Liu, Guangming Zhong, Yuanjun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chlamydia muridarum
attenuated rectal vaccine
pGP3S
mucosal immunity
rectal immunization
genital tract infection
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1550455/full
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