Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study

IntroductionChildhood traumatization can result in physical and mental health problems in adulthood, such as post-traumatic stress disorder (PTSD), which negatively influences quality of life and social functioning. Although evidence based trauma treatments benefit clients with PTSD after childhood...

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Main Authors: Annemieke C. Kamstra, Sybolt O. de Vries, Maarten F. Brilman, Petty Vasilev, Manna A. Alma, Antoinette D. I. van Asselt, Mia De Wolf, Robert A. Schoevers, Frederike Jörg
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Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Psychiatry
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Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1538267/full
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author Annemieke C. Kamstra
Annemieke C. Kamstra
Sybolt O. de Vries
Maarten F. Brilman
Petty Vasilev
Manna A. Alma
Antoinette D. I. van Asselt
Antoinette D. I. van Asselt
Mia De Wolf
Robert A. Schoevers
Frederike Jörg
author_facet Annemieke C. Kamstra
Annemieke C. Kamstra
Sybolt O. de Vries
Maarten F. Brilman
Petty Vasilev
Manna A. Alma
Antoinette D. I. van Asselt
Antoinette D. I. van Asselt
Mia De Wolf
Robert A. Schoevers
Frederike Jörg
author_sort Annemieke C. Kamstra
collection DOAJ
description IntroductionChildhood traumatization can result in physical and mental health problems in adulthood, such as post-traumatic stress disorder (PTSD), which negatively influences quality of life and social functioning. Although evidence based trauma treatments benefit clients with PTSD after childhood abuse and comorbid personality disorders, they are less effective than in clients who were traumatized in adulthood, and drop-out is substantial. The current study aims to assess the effects of inpatient dialectical behavior therapy combined with prolonged exposure (DBT-PTSD) on severity of PTSD, dissociation, parasuicidal behavior and borderline personality disorder (BPD) in clients with severe PTSD and comorbid psychiatric disorders. Secondary outcomes are social functioning, quality of life, borderline and cluster C personality disorder symptoms as treatment predictors, treatment trajectories, clients’ experiences and health economic consequences.MethodsThe naturalistic, longitudinal Trauma Therapy Study is conducted from January 2019 until May 2025 in a mental healthcare center in the Netherlands. Clients with severe PTSD and comorbid conditions who are referred to inpatient DBT-PTSD are included into the study. Based on power analyses a total sample size of N=56 is needed. Measurements take place before the waiting list period, at pre- and posttreatment and at six- and twelve-months follow-up. Clients fill in a daily DBT-PTSD diary, which gives insight into individual symptom trajectories.ResultsStatistical analyses include two-sided paired samples t-tests, linear mixed model analyses and cost-effectiveness analyses. Qualitative interviews are conducted within two years posttreatment and analyzed using a phenomenological approach. We correct for chance capitalization by using a conservative α-level of.01. Multiple imputation is used to handle missing data.DiscussionResearch on the effects of integrated treatment programs for clients with severe PTSD and co-morbid conditions is scarce. This study extends current knowledge on the effects of inpatient DBT-PTSD on PTSD and BPD symptoms, clients’ social functioning and quality of life. In addition, it provides insight into individual symptom trajectories and experiences, inspiring future treatment improvements for clients with severe psychopathology.Trial registrationMedical Ethical Committee approval (NL669060018, RTPO1044/01.10.2018). Preregistration: Dutch registration database Centrale Commissie Mensgebonden Onderzoek and International Clinical Trials Registry Platform (NL-OMON46167/01.10.2018/https://trialsearch.who.int/Trial2.aspx?TrialID=NL-OMON46167).
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spelling doaj-art-d0beacb94d9d4814a34544ca9fcf9bbf2025-02-05T07:32:58ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-02-011610.3389/fpsyt.2025.15382671538267Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy studyAnnemieke C. Kamstra0Annemieke C. Kamstra1Sybolt O. de Vries2Maarten F. Brilman3Petty Vasilev4Manna A. Alma5Antoinette D. I. van Asselt6Antoinette D. I. van Asselt7Mia De Wolf8Robert A. Schoevers9Frederike Jörg10Research Department, GGZ Friesland, Leeuwarden, NetherlandsDepartment of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsResearch Department, GGZ Friesland, Leeuwarden, NetherlandsDepartment of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsResearch Department, GGZ Friesland, Leeuwarden, NetherlandsDepartment of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsResearch Department, GGZ Friesland, Leeuwarden, NetherlandsDepartment of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsIntroductionChildhood traumatization can result in physical and mental health problems in adulthood, such as post-traumatic stress disorder (PTSD), which negatively influences quality of life and social functioning. Although evidence based trauma treatments benefit clients with PTSD after childhood abuse and comorbid personality disorders, they are less effective than in clients who were traumatized in adulthood, and drop-out is substantial. The current study aims to assess the effects of inpatient dialectical behavior therapy combined with prolonged exposure (DBT-PTSD) on severity of PTSD, dissociation, parasuicidal behavior and borderline personality disorder (BPD) in clients with severe PTSD and comorbid psychiatric disorders. Secondary outcomes are social functioning, quality of life, borderline and cluster C personality disorder symptoms as treatment predictors, treatment trajectories, clients’ experiences and health economic consequences.MethodsThe naturalistic, longitudinal Trauma Therapy Study is conducted from January 2019 until May 2025 in a mental healthcare center in the Netherlands. Clients with severe PTSD and comorbid conditions who are referred to inpatient DBT-PTSD are included into the study. Based on power analyses a total sample size of N=56 is needed. Measurements take place before the waiting list period, at pre- and posttreatment and at six- and twelve-months follow-up. Clients fill in a daily DBT-PTSD diary, which gives insight into individual symptom trajectories.ResultsStatistical analyses include two-sided paired samples t-tests, linear mixed model analyses and cost-effectiveness analyses. Qualitative interviews are conducted within two years posttreatment and analyzed using a phenomenological approach. We correct for chance capitalization by using a conservative α-level of.01. Multiple imputation is used to handle missing data.DiscussionResearch on the effects of integrated treatment programs for clients with severe PTSD and co-morbid conditions is scarce. This study extends current knowledge on the effects of inpatient DBT-PTSD on PTSD and BPD symptoms, clients’ social functioning and quality of life. In addition, it provides insight into individual symptom trajectories and experiences, inspiring future treatment improvements for clients with severe psychopathology.Trial registrationMedical Ethical Committee approval (NL669060018, RTPO1044/01.10.2018). Preregistration: Dutch registration database Centrale Commissie Mensgebonden Onderzoek and International Clinical Trials Registry Platform (NL-OMON46167/01.10.2018/https://trialsearch.who.int/Trial2.aspx?TrialID=NL-OMON46167).https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1538267/fullDBT-PTSDstudy protocoldialectical behavior therapypost-traumatic stress disorderparasuicidal behaviorborderline personality disorder
spellingShingle Annemieke C. Kamstra
Annemieke C. Kamstra
Sybolt O. de Vries
Maarten F. Brilman
Petty Vasilev
Manna A. Alma
Antoinette D. I. van Asselt
Antoinette D. I. van Asselt
Mia De Wolf
Robert A. Schoevers
Frederike Jörg
Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study
Frontiers in Psychiatry
DBT-PTSD
study protocol
dialectical behavior therapy
post-traumatic stress disorder
parasuicidal behavior
borderline personality disorder
title Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study
title_full Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study
title_fullStr Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study
title_full_unstemmed Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study
title_short Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy study
title_sort inpatient dialectical behavior therapy combined with trauma focused therapy for ptsd and borderline personality disorder symptoms study design of the naturalistic trauma therapy study
topic DBT-PTSD
study protocol
dialectical behavior therapy
post-traumatic stress disorder
parasuicidal behavior
borderline personality disorder
url https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1538267/full
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